【Animal Modeling】-Evaluation of the effect of midazolam and butorphanol on anesthesia in mice before isoflurane anesthesia

To observe the anesthesia effect and internal environment stability of mice receiving midazolam combined with butorphanol before isoflurane anesthesia, and evaluate the safety...

2022-06-23

【Animal modeling】-The effect of liraglutide on the expression and mechanism of key enzymes PEPCK and G6pase in hepatic gluconeogenesis in diabetic mice

To observe the effect and mechanism of liraglutide on the expression of key enzymes glucose-6-phosphate (G-6-Pase) and phosphoenolpyruvate carboxylase (PEPCK) in hepatic gluconeogenesis in diabetic mice...

2022-06-23

【Animal Modeling】-Protective effect and mechanism of estrogen on oxidative stress injury of mouse osteoblast MC3T3-E1

To investigate the protective effect and mechanism of estrogen on mouse osteoblast MC3T3-E1 oxidative stress injury...

2022-06-22

【Animal Model】-Interventional effect of valsartan on the activity of rat glomerular mesangial cells induced by high glucose

To investigate the effect and mechanism of valsartan on the proliferation and apoptosis of rat renal cells induced by high glucose...

2022-06-22

【Animal modeling】-The lipid-lowering effect of citrus polymethoxyflavonoid biscuits on hyperlipidemia mice

This study was the first to evaluate the lipid-lowering effect of adding citrus polymethoxyflavone powder to biscuits by measuring lipid metabolism experimental indicators in a hyperlipidemia mouse model, aiming to provide a new functional food for d...

2022-06-22

【Animal Modeling】-Effect of ubiquitin carboxyl-terminal hydrolase 1 gene deletion on the reproductive system development of female mice

To study the effect of ubiquitin carboxyl-terminal hydrolase L1 gene deletion on the reproductive system of female mice...

2022-06-22

【Animal modeling】-Promoting effect and mechanism of umbilical cord blood mononuclear cells on angiogenesis in rats with acute myocardial infarction

To investigate the effect and mechanism of umbilical cord blood mononuclear cells (HCMNCs) on angiogenesis in rats with acute myocardial infarction (AMI)...

2022-06-22

【Animal Modeling】-Systematic evaluation of the effects of placental differentially expressed proteins on the growth and development of placenta in a rat model of gestational diabetes mellitus

To systematically evaluate the effect of placental differentially expressed proteins on the growth and development of placenta in a rat model of gestational diabetes mellitus...

2022-06-22

【Animal modeling】-The effect of paeoniflorin on Bayk8644-induced depression-anxiety-like behavior in rats and its mechanism

To investigate the pharmacological mechanism of paeoniflorin in improving depression-anxiety-like behavior in rats based on L-type voltage-dependent calcium channel...

2022-06-22

【Animal Modeling】-Knockout of Leptin Receptor Causes Activation of Microglia in Rat Brain Tissue

To analyze the morphological and functional changes of microglia in the brain of leptin receptor (LEPR) knockout rats, and to explore the function of leptin receptor in microglia. effect....

2022-06-22

【Animal modeling】-Changes of C-reactive protein and inflammatory factors in Pterima pig model of plateau multiple organ dysfunction syndrome

To study the changes of tumor necrosis factor-α, interleukin-1β and C-reactive protein in the process of inflammatory reaction in the Phenma pig model of plateau multiple organ dysfunction syndrome...

2022-06-22

【Animal modeling】-Protective effect of curcumin on acute kidney injury in pregnant hypertensive rats

To investigate the protective effect of curcumin on acute kidney injury induced by gestational hypertension in rats and explore its potential mechanism...

2022-06-22

【Animal Modeling】-Experimental Study on Lung Tissue Injury Induced by Dental Grinding Dust in Rats

To evaluate the effects of three kinds of dental grinding dusts of cobalt-chromium-molybdenum metal (trade name: Vitaline), zirconium dioxide porcelain and polymethyl methacrylate resin on lung tissue injury in rats...

2022-06-22

【Animal modeling】-Effect of Naoshuantong capsule on the expression of inflammatory factors in aorta of ApoE-/- mice

To observe the effect of Naoshuantong capsule on the expression of inflammatory related factors interleukin-1β, interleukin-6, tumor necrosis factor, intercellular adhesion molecule-1 and metalloproteinase-9 in ApoE-/- atherosclerosis mouse model. Th...

2022-06-22

【Animal Modeling】-Establish a safe and effective method for obtaining liver and kidney samples by in vivo puncture of rhesus monkeys under the guidance of B-ultrasound

To analyze the variation trends and gender differences of organ coefficient, intestinal length and body size in SJ5-SPF chickens of different ages, and to provide experimental data for the sex selection of experimental animals...

2022-06-21

【Animal modeling】-Effect of curcumin on glucose transport and PI3K/Akt signaling pathway in adipocytes of type 2 diabetic rats

To investigate the effect of curcumin on glucose transport and phosphatidylinositol kinase-3 (PI3K)/protein kinase B (Akt) signaling pathway in adipocytes of type 2 diabetes mellitus (T2DM) rats...

2022-06-21