[Animal Modeling - Pharmacological Evaluation] - Acanthamoeba Keratitis Model

Acanthamoeba keratitis is a rare and severe chronic progressive corneal disease...

2024-09-23

[Animal Modeling - Pharmacological Evaluation] - Acute Compression Animal Model of Lumbar Nerve Root

Adult healthy New Zealand white rabbits, with an average weight of 2.3kg, half male and half female; Medications: 10% chloral hydrate, 75% alcohol, iodine, penicillin...

2024-09-23

[Animal Modeling - Pharmacological Evaluation]- Rat Sciatic Nerve Clamp Injury Model

　　Surgery was performed under intraperitoneal anesthesia with pentobarbital (0.4mg/kg) and sterile conditions. A longitudinal incision was made on the lateral side of the left lower limb of the animal, and a specially designed vascular clamp was used...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Preparation of Doxorubicin Mouse Cardiomyopathy Model

Wistar rats were intraperitoneally injected with doxorubicin at a dose of 2.5mg/(kg · time), 3 times per week, with an interval of 2 weeks, followed by 1 week for a total of 6 times, with a total dose of 15mg/kg. After the last injection was complete...

2024-09-23

[Animal modeling - efficacy evaluation] - transgenic diabetes animal model

Bruning et al. introduced ineffective alleles of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1) into mice through double heterozygosity, resulting in a decrease in IR/IRS-1 expression in the mice...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Spontaneous Animal Tumor Model

A type of tumor that naturally occurs in experimental animal populations without conscious artificial experimental treatment is called spontaneous tumor...

2024-09-23

[Animal modeling - Drug efficacy evaluation] - Myocardial ischemia model induced by vascular stenosis controller

Animal: Pitman Moore strain miniature pig, 7 months old, weighing 40kg; Medications: Ketamine, Atropine, Halothane, O2, CO2; Instruments: Surgical instruments, biological function experimental systems, artificial respirators, ameroid resin vascular s...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Preparation of Furazolidone Mouse Cardiomyopathy Model

Wistar rats were treated with 700 × 10 ^ -6 furazolidone added to drinking water (700mg furazolidone per kilogram of water) and observed for 12 weeks...

2024-09-23

[Animal modeling - efficacy evaluation] - diabetes cataract animal model

Fuhashi et al. selected 36 Charles River rats and injected streptozotocin (100mg/kg) intraperitoneally to make diabetes animal models...

2024-09-23

[Animal modeling - efficacy evaluation] - Preparation of diabetes cardiomyopathy model

After feeding a high sugar and high fat diet (10% lard, 20% sucrose, 2% cholesterol, 1% sodium cholate, 67% conventional feed) for 4 weeks, venous blood was collected for fasting (fasting for 10 to 12 hours, during which free drinking water) blood gl...

2024-09-23

[Animal modeling - Drug efficacy evaluation] - Rapid ventricular pacing preparation of canine dilated cardiomyopathy model

Six adult hybrid dogs with a weight of (17.04 ± 2.03) kg were used as experimental animals...

2024-09-23

[Animal Modeling - Pharmacological Evaluation] - Pig Acute Myocardial Ischemia Model

Animal: Experimental miniature pig, both male and female, weighing (16 ± 3.0) kg; Medication: Pentobarbital; Equipment: RM-6008 8-channel physiological recorder...

2024-09-23

[Animal Modeling - Efficacy Evaluation] - Malassezia Infection Animal Model

There are 7 species of filarial parasites that parasitize the human body, of which only Bansheen filarial and Malay filarial are prevalent in China...

2024-09-23

[Animal modeling - Drug efficacy evaluation] - Electrical stimulation induced myocardial ischemia model

Electrical stimulation of the dorsal medial nucleus of the hypothalamus and the optic nerve edge area on the right side of the animal. Stimulation parameters: wave width of 0.2ms, frequency of 50 times/s, weak stimulation (12V) and strong stimulation...

2024-09-23

[Animal Modeling - Efficacy Evaluation] - Animal Model of Fecal Nematode Infection

The fecal roundworm is the only worm that has both complete free living and parasitic generations...

2024-09-23

[Animal modeling - Drug efficacy evaluation] - Coronary artery balloon induced myocardial ischemia model

After anesthetizing the animal, artificial respiration is performed. After opening the chest through the left 4th or 5th intercostal space, the left anterior descending branch of the coronary artery is separated by about 1cm (or a segment of the left...

2024-09-23