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![[Animal modeling - Drug efficacy evaluation] - Chemical induced fatty liver model](/./uploads/images/default/default.png)
Administer 0.15% carbon tetrachloride (CCk) 10mg/kg body weight to mice at once, or inject D-galactosamine (D-Gal) 800mg/kg body weight intraperitoneally...
2024-09-02Adult rats were fed a high-fat diet containing 2% cholesterol, 10% lard, 0.3% sodium cholate, and other ingredients daily for 8 weeks, or adult rabbits were fed a high-fat diet containing 1% cholesterol and 10% lard at 40g/kg body weight and a high c...
2024-09-02Implant a gastric tube into the rat during surgery and inject ethanol and other nutrients daily using a liquid pump device. Ethanol accounts for 47% of total calories to maintain an ethanol concentration of 200-300mg/dl (2000-3000mg/L) in animal bloo...
2024-09-02Feed rats with liquid food containing only complete nutrients and alcohol daily. This food is prepared by calories, including 18% protein, 21% fat, 47% sugar (with 36% of calories replaced by alcohol), as well as some vitamins and inorganic salts...
2024-09-02Adult male Wistar rats were fed with conventional standard feed, and their drinking water was changed to 10% ethanol beverage. At the same time, they were orally administered 10ml/kg body weight of 50% ethanol twice a day (with a 12 hour interval) fo...
2024-09-02Adult rats were fed a high-fat diet (supplemented with 1% cholesterol and 5% lard on top of a low-fat diet) for one week after normal feeding. At the same time, they were orally administered with 1.5ml/kg body weight of 60% ethanol twice a day for 12...
2024-09-02All animals were weighed before the experiment and deprived of water for 24 hours. Those who lost more than 10% of their body weight entered the experiment and were randomly divided into two groups: the model group [acute renal failure (ARF) group]: ...
2024-09-02Lysine antagonism is the earliest animal model established for antidepressant research after the discovery that monoamine oxidase inhibitors and tricyclic antidepressants can counteract the abnormal behavior caused by Lysine. It is commonly used for ...
2024-08-30Due to their susceptibility to dermatophytosis, guinea pigs often develop spontaneous dermatophytosis, making them an ideal animal model for studying dermatophytosis; In addition, there have also been reports of a rabbit model of dermatophyton...
2024-08-30Animal: Male SD rats, weighing 180-250g; Medication: 50% glycerol...
2024-08-3015% egg yolk powder, 0.5% cholesterol, 5% lard, 79.5% basic feed, fed for 6 weeks to form a mold...
2024-08-29Rapid atrial stimulation has various effects on the electrical activity of atrial cells, such as shortening the effective refractory period (AERP) of the atrium, increasing the heterogeneity (non-uniformity or dispersion) of AERP, and slowing down lo...
2024-08-29On the 7th and 14th day after removing one kidney, animals were injected twice with 5mg/kg of daunorubicin via tail vein...
2024-08-29Spinal cord compression is one of the important causes of spinal cord injury. This injury model mainly simulates spinal cord injury caused by space occupying lesions in the spinal canal, which can be divided into acute compression injury and chronic ...
2024-08-28The principle of platform sleep deprivation is to utilize the living habits of rats, which are afraid of water and unable to enter sleep in water. By placing a platform in a water tank, the rats can stand on the platform. Due to the small diameter of...
2024-08-28Intramuscular injection of 12mg/kg mercuric chloride solution into modeling animals...
2024-08-28