[Animal modeling] The protective effect of -γ-secretase inhibitor on the white matter damage of neonatal rats induced by hyperoxia exposure

To explore the effect of γ-secretase inhibitor (N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester, DAPT) on the brain white matter damage of neonatal mice exposed to normal pressure and high concentration oxygen Role in...

2021-07-13

【Animal Modeling】-The protective effect of piperphentonamine hydrochloride on gentamicin-induced hearing damage in guinea pigs

Cochlear autophagy-related proteins beclin1 and LC3, Na + -K + -2Cl- complex transporter (NKCC1) mRNA, endoserine (ET) expression, cochlear gentamicin (GM) damage and pipefenone amine hydrochloride (PPTA) Observe relationship protection and damage me...

2021-07-13

Immune protection of Sap2 protein and dendritic cells against systemic Candida albicans infection

Immunize mice with recombinant protein and dendritic cells (DC) to observe its protective effect on systemic Candida albicans...

2021-07-13

Effect of chronic intermittent hypoxia on the expression of glucose transporter 4 in skeletal muscle of rats

To investigate the effects of inflammatory factors caused by chronic intermittent hypoxia-reoxygenation on glucose metabolism and skeletal muscle glucose transporter 4 (GLUT-4) expression in rats...

2021-07-13

【Animal Modeling】-The changes in the EEG activity of the submarginal zone in morphine-dependent rats during the period of drug-seeking subsidence

To explore the effect and mechanism of the changes in EEG activity in the subliminal cortex on the drug-seeking behavior during the sinking process of morphine-dependent rats...

2021-07-13

Experimental study on the changes of platelet mitochondria after tourniquet limb ischemia-reperfusion injury in rats

Targeting rapamycin to inhibit mTOR and study its effect on the proliferation of rat heart valve interstitial cells...

2021-07-13

【Animal Modeling】-The effect of rapamycin on the proliferation of rat aortic valve interstitial cells

Targeting rapamycin to inhibit mTOR and study its effect on the proliferation of rat heart valve interstitial cells...

2021-07-13

【Animal Modeling】-Study on the subacute inhalation toxicity of Ivermectin to rats

Study the subacute inhalation toxicity of ivermectin to rats and find the maximum unaffected dose...

2021-07-13

【Animal Modeling】-Effect of alcohol exposure during pregnancy on basic rhythmic respiratory discharge in medulla oblongata of newborn rats

To explore the effect of alcohol exposure during pregnancy on the basic rhythmic respiratory discharge activity (RRDA) of the medulla oblongata slices of newborn rats...

2021-07-12

To observe the inducing effect of temozolomide on the programmed death of rat glioma C6 cells and its possible molecular mechanism

To observe the inducing effect of temozolomide on the programmed death of rat glioma C6 cells and its possible molecular mechanism...

2021-07-12

【Animal Modeling】-High-intensity focused ultrasound inhibits the metastasis of mouse melanoma cells B16-F10 in vivo

To study the effect of high-intensity focused ultrasound (HIFU) treatment on the metastasis of melanoma cells in a mouse model of melanoma...

2021-07-12

【Animal Modeling】-The role of KA1 subreceptor in the death of hippocampal neurons caused by endoplasmic reticulum stress

To explore the role of up-regulation of KA1 subreceptor expression in the death of hippocampal neurons caused by endoplasmic reticulum stress...

2021-07-12

【Animal Modeling】-Effects of repeated hypoxic preconditioning on liver injury caused by renal ischemia-reperfusion in rats

To study the effect of repeated hypoxic preconditioning (RHP) on liver injury caused by renal ischemia-reperfusion injury (IRI) in rats, and to preliminarily explore its mechanism of action...

2021-07-12

[Animal modeling]-Chloroquine inhibits airway hyperresponsiveness in asthmatic mice

To explore the effect of chloroquine on airway hypersensitivity in asthmatic mice and its possible mechanism...

2021-07-12

Minocycline inhibits hyperpolarization activation currents of glial neurons in the spinal dorsal horn of rats

To study the effect of minocycline on the hyperpolarization activation current (Ih) of rat dorsal horn glial (SG) neurons...

2021-07-12

【Animal Modeling】-The effect of hydrogen sulfide on myocardial fibrosis and the expression of MAPK1/3 and MMP-8 in diabetic rats

To explore the effect of gas signal molecule hydrogen sulfide (H2S) on myocardial fibrosis and the expression of MAPK1/3 and MMP-8 protein in diabetic rats...

2021-07-12