[Animal experiment]-The effect of thalidomide on bisphosphonate-related osteonecrosis of the jaw

To study the effect of thalidomide on bisphosphonate-related osteonecrosis of the jaw...

2020-08-24

[Animal experiment]-Protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury in rats

To study the protective effect of apelin-13 on focal cerebral ischemia-reperfusion injury in rats and its possible mechanism...

2020-08-24

【Animal Experiment】-The effect of morroniside on the expression of hepatocyte growth factor and von Willebrand factor in cerebral ischemia-reperfusion rat cortex

To study the effect of moloneside on the expression of hepatocyte growth factor (HGF) and von Willebrand factor (vWF) in rat cortex after 7 days of cerebral ischemia and reperfusion...

2020-08-24

[Animal experiment]-The protective effect of Nrf2 antioxidant pathway in CCl4 induced acute liver injury in rats

To study the protective effect of Nrf2 oxidative damage pathway on CCl4-induced acute liver injury in rats...

2020-08-24

[Animal experiment] The protective effect of -γ-secretase inhibitor on the white matter damage of neonatal rats induced by hyperoxia exposure

γ-secretase inhibitor (N- [N-(3,5-difluorophenylacetyl)-L-alanyl]-S-phenylglycine butyrate, DAPT) exposed to atmospheric pressure and high oxygen concentration Investigate the effect on white matter damage in newborn mice...

2020-08-22

[Animal experiment]-The mechanism of transient receptor potential channel C1 in airway remodeling in guinea pig asthma and the intervention effect of budesonide

To explore the mechanism of TRPC1 ion channel in the development of airway remodeling, and to interfere with the intervention of budesonide by blocking the expression of transient receptor potential channel C1 (TRPC1)...

2020-08-22

【Animal experiment】-Effects of bis(2-ethylhexyl) phthalate exposure during pregnancy on growth and development of mouse placenta

The in vivo effects of DEHP exposure on mouse placental growth and development, maternal-fetal interface uNK cell number and angiogenesis through exposure to bis(2-ethylhexyl) phthalate during pregnancy...

2020-08-22

[Animal experiment]-Protective effect of piperphentonamine hydrochloride on gentamicin-induced hearing damage in guinea pigs

Guinea pig cochlear autophagy-related proteins beclin1 and LC3, Na + -K + -2Cl-complex transporter (NKCC1) mRNA, endothelin (ET) expression and cochlear gentamicin (GM) damage and pefentamine hydrochloride The relationship between salt...

2020-08-22

【Animal Experiment】-Ghrelin\'s Effect on Hippocampal DKK-1 Expression and Learning and Memory Function of Diabetic Rats

Observe the expression changes of Ghrelin on DKK-1 and WNT signaling pathways in diabetic rats, and explore the mechanism of its involvement in learning and memory functions...

2020-08-22

[Animal experiment]-Expression and significance of basic leucine zipper transcription factor ATF-like protein in kidney tissue of lupus mice

To explore the expression of leucine zipper gene transcription factor ATF-like protein (basucucinezipper transcription factor, ATF-like, BATF) in the kidney tissue of lupus mice and its clinical significance...

2020-08-22

[Animal experiment]-RNA interference specifically blocks the effect of local angiotensin Ⅱ type 1 receptors on first-phase insulin secretion

Observe the changes in the first phase insulin secretion of pancreatic islets in db/db mice after blocking the expression of local angiotensin II type 1 receptor (AT1R) by RNA interference technology and explore its underlying mechanism...

2020-08-22

【Animal Experiment】-The effect of rapamycin on the proliferation of rat aortic valve interstitial cells

Using rapamycin as a target to inhibit mTOR and study its effect on the proliferation of rat heart valve stromal cells...

2020-08-22

[Animal experiment]-Study on subacute inhalation toxicity of Ivermectin to rats

To study the subacute inhalation toxicity of ivermectin to rats to achieve the maximum unobserved effect level...

2020-08-22

[Animal Experiment]-Study the changes of platelet mitochondria after tourniquet limb ischemia-reperfusion injury

Explore the changes of platelet mitochondria after tourniquet ischemia-reperfusion injury, and provide guidance on the clinical application of hemostasis...

2020-08-22

[Animal experiment]-The effect of apoptosis signal regulatory protein 1 on the expression of GFAP, vimentin and hind limb motor function after spinal cord injury in rats

To explore the expression of apoptotic signal regulatory protein 1 (ASK1) in the glial scar after spinal cord injury (SCI), the expression of its protein, glial fibrillary acidic protein (GFAP) and vimentin (vimentin) and its effect on the hind limbs...

2020-08-22

[Animal experiment]-The changes of telemetry EEG activity in the submarginal zone of morphine-dependent rats during the period of drug-seeking subsidence

To explore the effect and mechanism of changing the subconscious cortex (IL) telemetry EEG activity on drug-seeking behavior in the process of drug withdrawal in morphine-dependent rats...

2020-08-22