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【Animal model】-Portal hypertension model caused by ligation of the common bile duct

【Animal model】-Portal hypertension model caused by ligation of the common bile duct

Reproduction method Anesthetize male Wistar rats weighing 200-250 g by intraperitoneal injection of 30 mg/kg pentobarbital sodium. Cut the abdominal midline on each layer of the abdominal wall and separate the common bile duct...

2020-08-06
【Animal model】-Thioacetamide-induced portal hypertension model in rats

【Animal model】-Thioacetamide-induced portal hypertension model in rats

Replication method Male Wistar rats weighing 150-200 g are injected intraperitoneally with 50 mg/kg of 3% thioacetamide (TAA) once a day for 16 weeks...

2020-08-06
[Animal model]-Rat model of portal hypertension with carbon tetrachloride liver cirrhosis

[Animal model]-Rat model of portal hypertension with carbon tetrachloride liver cirrhosis

Replication method 230-250 g male SD rats were intraperitoneally injected with CCl4 at a dose of 0.15 ml/kg body weight twice a week, and 0.4 g/L phenobarbital solution was used as drinking water for 4 weeks. , Causing a model of chronic liver injury...

2020-08-06
【Animal model】-Canine model of portal hypertension with carbon tetrachloride liver cirrhosis

【Animal model】-Canine model of portal hypertension with carbon tetrachloride liver cirrhosis

Breeding method: Adult experimental dogs are gavaged with CCl4 at a dose of 2 ml/kg body weight twice a week and once a week, and then gavage with 3% sodium pentobarbital after 12 weeks...

2020-08-06
【Animal Model】-Genetic Engineering Atherosclerosis Model

【Animal Model】-Genetic Engineering Atherosclerosis Model

Replication method 6-8 weeks old ApoE gene-deficient mice (C57BL/6J strain), male 18-20g, female half, ω (fat) = 21%, ω (cholesterol) = 0.15%. \"Western diet\" feed (60CO sterilization radiation treatment), feeding condition is level 2, roo...

2020-08-06
【Animal Model】-Destructive hypothalamic arcuate nucleus atherosclerosis model

【Animal Model】-Destructive hypothalamic arcuate nucleus atherosclerosis model

Replication method Neonatal Wistar rats are injected with 10% sodium glutamate (sodium glutamate, MSG) at a dose of 4 g/kg body weight on the 1, 3, 5, 7 and 9 days after birth...

2020-08-06
How to prepare an animal model of rabbit atherosclerotic plaque caused by carotid artery balloon dilatation?

How to prepare an animal model of rabbit atherosclerotic plaque caused by carotid artery balloon dilatation?

Breeding method An experimental male rabbit weighing about 1.5 kg was anesthetized by intravenous injection of 25% urethane at 1 g/kg body weight, and the right common carotid artery (CCA), right internal carotid artery (ICA) and right outside of the...

2020-08-06
【Animal model】-High methionine atherosclerosis model

【Animal model】-High methionine atherosclerosis model

The male of the replication method experimental rabbit weighs 2.0 to 2.5 kg. After 15 days of adaptive feeding, feed with high methionine feed (standard rabbit feed plus 1% methionine) for 8 weeks...

2020-08-06
How to prepare a rat model of atherosclerosis induced by vitamin D?

How to prepare a rat model of atherosclerosis induced by vitamin D?

Breeding method: Male Wistar rats weighing 180-200g were injected intraperitoneally with 600,000 U/kg of vitamin D and fed with a basic diet...

2020-08-06
How to prepare animal model of macaque cerebral atherosclerosis?

How to prepare animal model of macaque cerebral atherosclerosis?

Replication method In experimental monkeys aged 10 to 16 years, 50-75 mg/kg of epinephrine was intravenously injected once a week. After the epinephrine was stopped, a high-fat diet with 1% cholesterol added 6 times for every 150 g...

2020-08-06
How to prepare quail atherosclerosis animal model?

How to prepare quail atherosclerosis animal model?

Breeding methods Male quails weigh 90-110g and are 5-6 weeks old. Feed containing 1% cholesterol, 1% lard and 1% soybean oil...

2020-08-06
How to prepare a rabbit model of atherosclerosis caused by high-fat and high-cholesterol diet?

How to prepare a rabbit model of atherosclerosis caused by high-fat and high-cholesterol diet?

Breeding method New Zealand rabbits weigh 2.0 to 2.5 kg and are about 3 to 4 months old. One week after observation, they are fed with 1.5% cholesterol 80 g/(kg to d) feed, free drinking water, and 12 animals per week. After feeding the animals for 1...

2020-08-06
【Animal model】-Hypertension model caused by medullary nerve compression

【Animal model】-Hypertension model caused by medullary nerve compression

Copy method After conventional anesthesia, the experimental dog was intubated, the right femoral artery was intubated, and the blood pressure was monitored by a multi-channel physiological recorder...

2020-08-06
[Dòngwù móxíng]-yìng jī xìng gāo xiěyā móxíng 15/5000 [Animal model]-Stress-induced hypertension model

[Dòngwù móxíng]-yìng jī xìng gāo xiěyā móxíng 15/5000 [Animal model]-Stress-induced hypertension model

Unconditional stimulation (epinephrine, angiotensin, electrical stimulation, etc.) is repeatedly combined with conditional stimulation to induce hypertension. This can be done by dogs, rats, rabbits and other animals...

2020-08-06
[Animal model]-Hypertension model caused by removal of baroreceptor afferent nerve

[Animal model]-Hypertension model caused by removal of baroreceptor afferent nerve

Refers to high blood pressure caused by blocking the aortic decompression nerve and carotid sinus nerve in animals. Dogs and rabbits are commonly used in experiments, sometimes rats...

2020-08-06
【Animal model】-Deoxycorticosterone (DOC) salt hypertension model

【Animal model】-Deoxycorticosterone (DOC) salt hypertension model

Feeding method Anesthetize the experimental rat, cut the midline of the abdomen, and remove the left kidney...

2020-08-06