[Animal modeling] - Experimental pulmonary edema model induced by nitrogen tetroxide in rats

Animals in the modeling group were induced to inhale N2O4 [concentration of (352 ± 21) mg/m3] for 0.5 hours to replicate an acute pulmonary edema model. The method is to take 25 μ l of liquid N2O4 for the first time, inject it into a 120L toxicity ca...

2024-06-03

[Animal modeling] - Acute pulmonary edema in rats

Model group animals were anesthetized intraperitoneally with pentobarbital 30mg/kg body weight, femoral artery was separated, intubation was performed, and blood pressure was measured; Separate the jugular vein, intubate, monitor with an oscilloscope...

2024-06-03

[Animal modeling] - Experimental model of recurrent pulmonary edema

Animal: Healthy rabbit, weighing 2.5-3.5kg, both male and female; Medication: pentobarbital; Equipment: 12F chest tube equipped with a valve (modified from a 12F catheter with a valve installed at the end of the urine bag), 60ml syringe...

2024-06-03

[Animal modeling] - Physiological saline induced pulmonary edema animal model

After anesthesia, the animal in the modeling group is cut open in the neck, separated from the skin, and intubated with the trachea, one artery, and the other vein. Normal breathing, blood pressure, and lung breathing sounds are recorded. A large amo...

2024-06-03

【Animal modeling】 - Ammonium chloride induced pulmonary edema animal model

Animals in the modeling group were intraperitoneally injected with 0.6ml/100g of ammonium chloride (rat, drug concentration 6%), 0.15ml/10g of body weight (mouse, drug concentration 3%), and 0.5-0.7ml/kg (guinea pig, drug concentration 6%)...

2024-06-03

[Animal modeling] - Establishment of a mouse model of adverse skin reactions induced by erlotinib

Elotinib is a new targeted drug for the treatment of non-small cell lung cancer. In recent years, it has been widely used in clinical practice, but there are many side effects, among which rash is the most common, and it is most difficult for patient...

2024-06-03

【Animal modeling】-Effect of metformin on cognitive dysfunction and PI3K/Akt pathway in Alzheimer\\\\\\\\\\\\\\\\

To investigate the effect of metformin on phosphatidylinositol-3-kinase/protein kinase B pathway and cognitive dysfunction in Alzheimer\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\'s disease rats...

2024-06-03

[Animal modeling] - Comparison of effects of different exercise modes on MSTN and IGF1 of skeletal muscle in rats

To explore the effects of different exercise modes on MSTN and IGF1 of skeletal muscle in rats, and provide theoretical basis for selecting appropriate exercise modes to improve skeletal muscle function...

2024-06-03

【Animal Modeling】-A study on the combination of disease and syndrome of atherosclerosis (Qi stagnation and blood stasis syndrome) in rats

To construct a rat model of atherosclerosis combined with disease and syndrome, and to provide an evaluation tool for the pharmacodynamics study of the corresponding traditional Chinese medicine...

2024-06-03

[Animal modeling] - Establishment of long-term survival rat model of moderate and severe sepsis

To establish a long-term survival rat model of moderate and severe sepsis, observe the natural course of sepsis, and provide new ideas and methods for the study of sepsis...

2024-06-03

[Animal Modeling] - Based on SDF-1/CXCR4 axis, observe the effect of Jisheng Shenqi Decoction on the homing of BMSCs in cirrhotic rats

To investigate the effect of Jisheng Shenqi Decoction on the homing efficiency of bone marrow mesenchymal stem cells through the 4 axis of stromal cell derived factor-1/CXC chemokine receptors, and to analyze the mechanism of its combination with BMS...

2024-05-31

【Animal Model】-Experimental stress-induced impairment of mouse welfare and the effect of music intervention

To explore the degree of damage to animal welfare caused by routine experimental operations and the effect of music intervention...

2024-05-31

【Animal modeling】-Changes and significance of oxidative stress and cytokines in the formation of non-alcoholic fatty liver disease in gerbils

To study the dynamic changes and significance of oxidative stress and cytokines in the formation of nonalcoholic fatty liver disease (NAFLD) in gerbils...

2024-05-31

[Animal Modeling ]- Persistent Regional Cerebral Ischemia Model Induced by Middle Cerebral Artery Infarction in Rats

Male SD rats, weighing 280-350g; Medication: Chloral hydrate, antibiotics...

2024-05-31

【Animal Modeling】-Effect of Maiqi Jiangtang Pill on blood sugar in ob/ob mice

To study the effect of Maiqi Jiangtang Pills on blood sugar in ob/ob mice...

2024-05-28

[Animal modeling] - Targeting recognition of heptamethine cyanine near-infrared fluorescent dye on orthotopic transplantation model of gastric cancer

To study the effect of heptamethine cyanine near-infrared fluorescence (NIRF) dye in vivo imaging of orthotopic gastric cancer transplantation model...

2024-05-28