[Animal experiment]-Cynomolgus monkey, dog, human: evaluation of interspecies differences in QTc interval prolongation caused by drugs

The most suitable animal species and the subsequent conversion to human concentration-effect relationship are key steps for accurate assessment of the pro-arrhythmic risk of candidate drugs. The purpose of this investigation is to quantitatively eval...

2020-08-26

【Animal Experiment】-Shanghai Jiaotong University and others have made new progress in the research of mouse female reproductive stem cells

Xiaodong Zhao\'s research group at Shanghai Jiaotong University and Ji Wu\'s research group at Bio-X Research Institute collaborated and discovered a histone modification tag specific to female reproductive stem cells labeled with enhancers...

2020-08-26

【Animal experiment】-bcl-2 gene modified neural stem cell transplantation to repair rat spinal cord injury

To investigate the effect of neural stem cell transplantation modified by bcl-2 gene on the recovery of neurological dysfunction in rats with spinal cord injury...

2020-08-26

[Animal Experiments]-\"Chimera\" experiment was re-funded, embryos can be used for organ transplantation

Scientists say that at least two sets of biological chimeras are composed of cells of different genotype chimeras. In a recent study, researchers transplanted human stem cells into pig embryos to produce this chimera....

2020-08-26

【Animal experiment】-The effect of bee venom on TrkA and TRPV1 in dorsal root ganglia of rats with collagen-induced arthritis inflammatory pain

To study the effect of bee venom on TrkA and TRPV1 pain signaling molecules in collagen-induced arthritis (CIA) rats...

2020-08-25

【Animal Experiment】-Immune system affects biological behavior

A team of biologists at the University of Virginia School of Medicine confirmed that human social activities may depend on the immune system...

2020-08-25

【Animal experiment】-Comparison of toxicity of doxorubicin liposome injection and doxorubicin injection after repeated administration in rats

To study the toxicity and toxicity of doxorubicin liposome injection and doxorubicin injection after continuous intravenous injection...

2020-08-25

[Animal experiment]-Lithium chloride compound calcium phosphate cement can promote the repair of tibia bone defects in rats

Observe the effect of calcium phosphate cement (CPC) and lithium chloride composite calcium phosphate cement (Li/CPC) on fracture healing in SD rats...

2020-08-25

[Animal Experiment]-Reward activation enhances immunity of mice

A recent study in mice published in \"Nature Medicine\" found that the activation of the reward center in the brain may affect the body\'s immune resistance to certain bacterial pathogens (E. coli)....

2020-08-25

【Animal Experiment】-Mice imaging research reveals the mechanism of brain navigation

Colombian scientists have discovered a key feature of the brain’s global positioning system that can help mice find what it seeks...

2020-08-25

【Animal Experiment】-The effect of microbial-derived antioxidants on sleep and antioxidant properties of mice

To study the effects of different doses of microbial-derived antioxidants on sleep and antioxidant properties in mice...

2020-08-25

【Animal Experiment】-The effect of polydatin on the expression level of miR-214 in the liver of ApoE-/- mice and liver function

To study the effect of resveratrol glycosides (PD) on liver miR-214 and liver function in ApoE-/- mice...

2020-08-25

【Animal Experiment】-Effects of different intervention programs of simvastatin on bone quality of osteoporotic rats

To study and compare the effects of simvastatin on bone loss and bone loss in ovariectomized rats...

2020-08-25

[Animal experiment] Effects of 5-HT-7 receptor agonist on the excitability of pyramidal neurons in the medial prefrontal cortex of Parkinson’s disease model rats

To study the effect of 5-hydroxytryptamine (5-HT)-7 receptor on the excitability of the pyramidal neurons in the medial prefrontal cortex (mPFC) of Parkinson’s disease (PD) rats...

2020-08-25

[Animal experiment]-Study on the effect of oral rehydration salt on reducing the mortality of rats with status convulsions with lithium chloride and pilocarpine

To find a way to reduce the mortality of the status epilepticus (SE) model caused by oral chlorinated rehydration salt (ORS) modified lithium chloride-pilocarpine by gavage...

2020-08-25

[Animal experiment]-Effect of exposure to ethinyl estradiol before pregnancy on the changes in glucose metabolism of the offspring of rats and the expression of genes related to liver glucose metaboli

Using SD rats as a model, observe the effects of prenatal exposure to ethinyl estradiol (EE) on the changes of glucose metabolism in the offspring and the expression of genes related to glucose metabolism in the liver...

2020-08-25