【Animal modeling】-Effect of lentiviral vector-mediated HCV receptor gene OCLN/CD81 transfection on tree shrew bone marrow mesenchymal stem cells

To observe the effects of lentiviral vector-mediated HCV receptor gene OCLN/CD81 transfection on the biological characteristics and gene expression of tree shrew bone marrow mesenchymal stem cells under in vitro culture conditions...

2024-01-17

【Animal Modeling】-Why do rodents in arid areas have high drug resistance?

Recently, the innovation team of grassland pest and rodent monitoring and prevention and control of the Institute of Plant Protection, Chinese Academy of Agricultural Sciences, by comparing the molecular evolution characteristics of drug resistance-r...

2024-01-16

【Animal Modeling】-The effect of long non-coding RNALINC00152 on the growth of human glioma xenografts in nude mice and its mechanism

The effect of U251 tumor-bearing mice on tumor growth and its mechanism were discussed...

2024-01-16

【Animal Modeling】-Effects of Unpredictable Stress Stimulation on the Immunity and Microflora of the Gastrointestinal Tract in Rats

To analyze the effects of unpredictable stress on the gastrointestinal immune system and microbial population by observing the rats after 9 days of unpredictable stress stimulation, so as to provide a reference for the study of chronic stress on gast...

2024-01-16

【Animal modeling】-Construction and evaluation of doxorubicin-induced chronic cardiotoxicity model in mice

To evaluate the modeling effect of different concentrations of doxorubicin-induced cardiotoxicity model in mice based on pathological changes...

2024-01-16

【Animal modeling】-C57BL/6J mouse frozen-thawed IVF prokaryotic embryos used for Cas9 microinjection

To explore the feasibility of using Cas9 injection in mice after in vitro fertilization freeze-thaw...

2024-01-16

【Animal modeling】-Inhibitory effect of resveratrol on blood hypercoagulability in rats and its relationship with the expression of NF-κB

To study the effect of resveratrol on the formation of hypercoagulable state in rats and its relationship with the expression of NF-κB...

2024-01-16

【Animal modeling】-Study on the effect of compound Ejiao paste on the endometrium of mice

To investigate the effect of Compound Ejiao paste on the endometrium of mice...

2024-01-16

【Animal Modeling】-Analysis of the effects of different hypoxia exposure modes on differential gene expression of rat tibialis anterior muscle based on RNA sequencing

To screen the differentially expressed genes and their related pathways in rat tibialis anterior muscle from chronic intermittent hypoxia exposure and acute hypoxia exposure...

2024-01-16

【Animal Modeling】-Exploring the neuroprotective effect of DAHP on brain trauma rats based on NOS pathway

To investigate the neuroprotective effect of 2,4-diamine-6-hydroxypyrimidine (DAHP) on traumatic brain injury rats, and to explore its possible mechanism...

2024-01-16

【Animal Modeling】-Application of intracavitary shunt plug in rat abdominal cavity heterotopic heart transplantation

To investigate the application of intravascular shunt thrombus in establishing a rat model of heterotopic heart transplantation in the abdominal cavity...

2024-01-15

[Animal Modeling]-Long-term survival rat model of moderate to severe sepsis

Establish a long-term survival rat model of moderate to severe sepsis, observe the natural development of sepsis, and provide new ideas and methods for the study of sepsis...

2024-01-15

【Animal Modeling】-Hemophilia Gene Therapy Animal Trials Successfully

Hemophilia is a disease caused by hereditary coagulation dysfunction, which is characterized by the inability of the body to produce coagulation factors or insufficient production of coagulation factors, resulting in prolonged coagulation time and di...

2024-01-15

【Animal Modeling】-Comparative Study on Visceral Hypersensitivity Models Induced by Combined Method

To observe the effect of maternal-infant separation combined with mechanical stimulation and drug combined with chronic stress on the visceral hypersensitivity model of irritable bowel syndrome, and to explore the advantages and disadvantages of the...

2024-01-15

【Animal modeling】-Cloning of IFITM3 gene in African green monkey and its tissue-specific expression differences

To study the function of interferon-induced transmembrane protein 3 in African green monkeys, as well as the mechanism and mode of its antiviral effect, the IFITM3 gene was cloned from different tissues and organs of African green monkeys, and the ex...

2024-01-15

【Animal Modeling】-Preparation of a mouse model of diarrhea-type irritable bowel syndrome induced by acetic acid combined with restraint stress

To establish a mouse model of diarrhea-predominant irritable bowel syndrome by rectal infusion of 3% acetic acid (AA) combined with restraint stress, and to evaluate the feasibility of the model...

2024-01-15