【Animal Modeling】-Tumor necrosis factor-α-induced protein-8-like molecule 2 promotes apoptosis of CD4-positive T cells in heat-injured mice

To investigate the effect of tumor necrosis factor-α-induced protein-8-like molecule 2 (TIPE2) on apoptosis of spleen CD4+ T lymphocytes in a mouse model of severe scald...

2023-11-21

[Animal modeling] - Preliminary study on rhesus monkey model infected by human coxsackie B2 virus

To provide experimental methods and technical support for the establishment of the infection model of human coxsackie virus B2 in rhesus monkeys, and lay a foundation for the follow-up research on its infection mechanism, pathophysiology, etc., throu...

2023-11-21

【Animal modeling】-Effect of Fkbp51 knockout on alternative splicing of mouse liver transcriptome

To study the effect of Fkbp51 knockout on gene alternative splicing in liver tissue by analyzing the expression profiles of Fkbp51 gene knockout and wild-type mice livers...

2023-11-21

[Animal modeling] Study on the improvement of renal function of type 1 diabetes mice by vEGF-A inhibitor sFLT-1

To investigate whether sFLT-1, a VEGF-A inhibitor, can reverse renal function damage in type 1 diabetes mice by inhibiting the activation of vascular endothelial cells and inflammatory response...

2023-11-21

【Animal modeling】-A modeling method of postnatal mouse restraint stress model and the production of restraint device

To create a self-made restraint device for mice, and to establish a postnatal mouse restraint stress model for related stress experiments...

2023-11-21

【Animal modeling】-Protective effect of stilbene glycosides inhibiting NADPH oxidase on cerebral ischemia/reperfusion injury in mice

To investigate the protective effect of stilbene glycoside (TSG) inhibiting NADPH oxidase on cerebral ischemia-reperfusion (I/R) injury in mice...

2023-11-21

【Animal modeling】-Construction and evaluation of non-thoracic aortic arch stenosis heart failure model in mice

To establish a stable and reliable mouse model of heart failure by non-thoracotomy aortic arch stenosis, and to analyze and observe the pathological process of heart failure in mice...

2023-11-21

[Animal modeling] - Establishment of preeclampsia rat model by improved method of reducing uterine blood flow perfusion

To explore the method of establishing preeclampsia rat model...

2023-11-21

[Animal modeling ]- denervated gastrocnemius muscle animal model

Healthy adult male SD rats, 150-200g; Medication: 1% pentobarbital...

2023-11-21

【 Animal modeling 】 - Chronic compressive sciatic nerve injury model

SD rats, female, 180-250g; Medication: Anesthetics...

2023-11-21

[Animal modeling ]- EAE model induced by spinal cord or white matter homogenate as antigen

Immunization of Wistar rats with guinea pig spinal cord homogenate to induce EAE model...

2023-11-21

【Animal Modeling】 - A Primate Hyperlipidemia Animal Model Induced by High Fat Feed

Rhesus monkey, 3-6 years old, male and female, weighing 3.5-10.5kg; Medication: High fat feed...

2023-11-21

【Animal Modeling】 - Hydroxylurea Method for Kidney Yang Deficiency Animal Model

Adult rats were fed hydroxyurea at a dose of 2.5g/kg body weight, 3 times per week, and kept for 90 days. They were free to ingest water and food. Subcutaneous injection of tetracycline hydrochloride (25mg/kg body weight) was administered to the rats...

2023-11-21

[Animal modeling] - Effect of carbon tetrachloride induced acute liver injury on the heart of rats

To investigate the effects of carbon tetrachloride on cardiac function and morphology in rats with acute liver injury...

2023-11-20

[Animal Modeling] - Adenine Method for Kidney Yang Deficiency Syndrome Animal Model

　　Adult rats were fed with a feed containing 0.5% adenine, with a daily dose of approximately 350mg/kg body weight. Changes in animal weight, body temperature, urine volume, demeanor, body hair, and activity were observed. On the 30th day of feeding,...

2023-11-20

[Animal Modeling] - Rat Chronic Pancreatitis Model

Male SD rats, weighing 180-200g; Medication: Dibutyl dichloride...

2023-11-20