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【Animal modeling】-The killing effect of PBLC of guinea pigs with different FMDV susceptibility on simulated FMDV-infected cells

【Animal modeling】-The killing effect of PBLC of guinea pigs with different FMDV susceptibility on simulated FMDV-infected cells

To investigate the genetic and immunological mechanisms of guinea pigs resistance to foot-and-mouth disease virus (FMDV). To elucidate the feasibility of FMDV pseudovirus-infected cells for studying FMDV pathogenesis...

2022-03-08
【Animal modeling】-Screening CA16 pathogenic related genes using genetically diverse mouse resources

【Animal modeling】-Screening CA16 pathogenic related genes using genetically diverse mouse resources

Coxsackievirus A16 is one of the main pathogenic pathogens of hand, foot and mouth disease, and its pathogenic mechanism is not yet clear....

2022-03-08
【Animal modeling】-Establishment and validation of electroporation transfection conditions for mouse macrophage RAW264.7 cells

【Animal modeling】-Establishment and validation of electroporation transfection conditions for mouse macrophage RAW264.7 cells

To screen and verify the conditions of electroporation for transfection of TRIB3 overexpression plasmid and TRIB3 siRNA in RAW264.7 cells, and to establish the optimal electroporation transfection scheme for RAW264.7 cells...

2022-03-08
【Animal modeling】-α-synuclein A53T mutation impairs cognitive function in mice

【Animal modeling】-α-synuclein A53T mutation impairs cognitive function in mice

To explore the changes of cognitive function, motor function, anxiety-like behavior and pathological changes in α-synuclein A53T transgenic mice...

2022-03-08
【Animal Modeling】-Relationship between the expression of related splicing factors and the inclusion rate of SMN2 exon 7 in SMA mice

【Animal Modeling】-Relationship between the expression of related splicing factors and the inclusion rate of SMN2 exon 7 in SMA mice

To study the inclusion of SMN2 exon 7 in different tissues of SMA mice, and to screen the related splicing factors...

2022-03-08
【Animal modeling】-Isolation, identification and drug sensitivity test of Proteus mirabilis from cynomolgus monkeys

【Animal modeling】-Isolation, identification and drug sensitivity test of Proteus mirabilis from cynomolgus monkeys

To provide theoretical and technical support for microbial detection of imported experimental monkeys and how to carry out feeding management and disease prevention and control by identifying and drug susceptibility testing of Proteus mirabilis isola...

2022-03-08
【Animal Modeling】- Histopathological study of skin healing in miniature pigs after deep second-degree burns

【Animal Modeling】- Histopathological study of skin healing in miniature pigs after deep second-degree burns

To establish a pig model of deep second-degree scald, and to observe the histopathological changes of skin repaired at different time points...

2022-03-08
【Animal Modeling】- Transcriptome Analysis of Human Cells Infected by Porcine Circovirus Type 2

【Animal Modeling】- Transcriptome Analysis of Human Cells Infected by Porcine Circovirus Type 2

Whether circovirus 2 can infect human cells has been a topic of debate...

2022-03-08
【Animal Modeling】-Optimization of Mouse Embryo Transfer Technology and Purification of Cytomegalovirus

【Animal Modeling】-Optimization of Mouse Embryo Transfer Technology and Purification of Cytomegalovirus

To establish a purification method for cytomegalovirus in mice to obtain mice without MCMV infection...

2022-03-07
【Animal Modeling】-Expression profile of TRIM26 in major tissues and organs of human and mouse

【Animal Modeling】-Expression profile of TRIM26 in major tissues and organs of human and mouse

To clarify the expression location and level of TRIM26 in different tissues and organs of human and mouse...

2022-03-07
【Animal modeling】-Gene cloning and preliminary functional study of junctional adhesion molecule A in tree ferrets

【Animal modeling】-Gene cloning and preliminary functional study of junctional adhesion molecule A in tree ferrets

To obtain the full-length coding sequence of junctional adhesion molecule A in tree ferrets and analyze its molecular characteristics, and to explore the mechanism of JAM-A as a receptor for reovirus invading primary lung cells of tree ferrets...

2022-03-07
【Animal modeling】-IVC cage changing standard operating procedures and the risk of transmission of mouse virus pathogens

【Animal modeling】-IVC cage changing standard operating procedures and the risk of transmission of mouse virus pathogens

To study the risk of virus infection in mice raised with IVC equipment in the standard operating procedure of cage changing in independent ventilation cages and laboratory animal negative pressure barrier facilities...

2022-03-07
【Animal modeling】-Gene cloning and preliminary functional study of junctional adhesion molecule A in tree ferrets

【Animal modeling】-Gene cloning and preliminary functional study of junctional adhesion molecule A in tree ferrets

To obtain the full-length coding sequence of junctional adhesion molecule A in tree ferrets and analyze its molecular characteristics, and to explore the mechanism of JAM-A as a receptor for reovirus invading primary lung cells of tree ferrets...

2022-03-07
【Animal modeling】-Establishment and application of TaqMan real-time quantitative PCR detection method for VP2 gene of mink Aleutian virus

【Animal modeling】-Establishment and application of TaqMan real-time quantitative PCR detection method for VP2 gene of mink Aleutian virus

To establish a convenient and sensitive fluorescent quantitative PCR method for detection of mink Aleutian virus (AMDV), so as to realize the rapid quantitative detection of AMDV in clinical samples...

2022-03-07
【Animal Modeling】-Small ubiquitin-like modifier protease 3 regulates autophagy in mouse alveolar type II epithelial cells

【Animal Modeling】-Small ubiquitin-like modifier protease 3 regulates autophagy in mouse alveolar type II epithelial cells

To investigate the regulatory effect and molecular mechanism of small ubiquitin-like modifier-specific protease 3 on autophagy in mouse lung tissue...

2022-03-04
【Animal modeling】-Validation of the effect of SPF golden hamster cage and drinking water pulsed vacuum sterilization

【Animal modeling】-Validation of the effect of SPF golden hamster cage and drinking water pulsed vacuum sterilization

To confirm the performance of the pulse vacuum sterilizer, and to verify the effect of pulse vacuum sterilization on the SPF golden hamster cage and drinking water under the specified loading method and sterilization conditions...

2022-03-04