【Animal modeling】-Protective effect of piperphentonamine hydrochloride on gentamicin-induced hearing loss in guinea pigs

To observe the relationship between guinea pig cochlear autophagy-related proteins beclin1 and LC3, Na+-K+-2Cl- co-transporter (NKCC1) mRNA, endothelin (ET) expression and cochlear gentamicin (GM) injury and piperphentonamine hydrochloride (PPTA) pro...

2022-03-01

【Animal modeling】-Protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury in rats

To investigate the protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury (CIRI) in rats and its possible mechanism...

2022-03-01

【Animal Modeling】-Effects of hesperidin on antioxidant activity and gene expression of antioxidant enzymes in mice

To investigate the effect of hesperidin on the antioxidant effect of the body...

2022-03-01

【Animal Modeling】-Metabolic rate determines primate brain development and lifespan

Researchers at Loyola University Chicago, co-authors of the groundbreaking study, found that humans have a higher metabolic rate than closely related primates, allowing humans to evolve to be larger brain...

2022-03-01

【Animal Modeling】-Aniline-induced DNA damage in mouse hepatocytes and lymphocytes and its repair effect

To study the genotoxicity of aniline and its repair kinetics...

2022-03-01

【Animal modeling】-Effect of octachlorodibenzodioxin on gene expression profile of mouse testis tissue

To investigate the effect of octachlorodibenzodioxins on the changes of gene expression profiles in the testis of male mice...

2022-03-01

【Animal modeling】-The protective effect of Zhenwu decoction on the heart of mice with uremic cardiomyopathy induced by most nephrectomy

To investigate the cardioprotective effect and mechanism of Zhenwu Decoction on uremic cardiomyopathy in mice...

2022-03-01

【Animal Modeling】-Effects of Four Commonly Used Experimental Anesthetics on Cardiovascular System of Rats

To investigate the effects of different animal experimental anesthetics on the cardiovascular system of rats...

2022-03-01

【Animal modeling】-Construction and effect evaluation of Noggin gene silencing expression vector

To construct lentivirus-mediated Noggin RNAi interference sequences, and to analyze the silencing effect of these interference sequences on Noggin gene...

2022-02-28

【Animal Modeling】-Effect of triptolide on the expression of Notch pathway receptors and ligand genes in rats with adjuvant arthritis pulmonary function

To observe the effect of triptolide (TPT) on the expression of Notch receptor and ligand in adjuvant arthritis (AA) rats...

2022-02-28

【Animal modeling】-Estrogen reduces microvascular injury induced by chronic hypoperfusion in rat brain by up-regulating VEGF expression

By detecting the pathological changes of cerebral microvessels in different periods after permanent ligation of bilateral common carotid arteries (BCCAO) in rats and the effect of physiological dose of 17-β-estradiol (E2) replacement therapy, to expl...

2022-02-28

【Animal modeling】-Effect of dexmedetomidine pretreatment on inflammatory factors and oxidative stress in rats with septic kidney injury

To investigate the effect of dexmedetomidine on inflammatory factors and oxidative stress of AKI (acute kidney injury) in septic rats...

2022-02-28

【Animal modeling】-New polycitric acid filler material induces soft tissue regeneration after rat skull defect

To evaluate the ability of two novel polycitric acid degradable biomaterials to induce soft tissue regeneration after calvarial defect in rats...

2022-02-28

【Animal Modeling】-Experimental study of CD45 mAb-mediated 188Re-avidin two-step pretargeting targeting lymphoma

To establish a CD45 mAb-mediated two-step pre-localization method for 188Re-avidin, observe its biological distribution in tumor-bearing mice, and evaluate its feasibility in the treatment of lymphoma...

2022-02-28

【Animal Modeling】-Research on the antidepressant mechanism of licorice and its application in animal behavior

Depression, also known as \"emotional cold\", is a common affective disorder characterized by persistent low mood...

2022-02-28

【Animal modeling】-Protective effect of myricetin on ischemia-reperfusion injury in isolated rat hearts

To study the protective effect and mechanism of myricetin on ischemia-reperfusion injury in isolated rat hearts...

2022-02-28