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Bleomycin (bleomycin) is a polypeptide anti-tumor drug, and its mechanism of causing pulmonary interstitial fibrosis is mainly through the action of reactive oxygen species. In the early stage of lung injury caused by bleomycin, that is, the alveolit...
2022-02-04Use transient receptor potential vanilloid type 4 (TRPV4) gene knockout (TRPV4-/-) mice to study the role of TRPV4 receptor in kidney damage caused by angiotensin II (angiotensin II, Ang II) effect...
2022-02-04Congestion syndrome (blood loss syndrome) is caused by qi deficiency, qi stagnation, hot toxins, cold blood, etc., blocking blood flow and accumulating in the meridians or organs...
2022-02-04Japan Institute of Physical Chemistry has developed a new type of bioluminescence system that can observe the brain activity of living animals...
2022-02-04In the design of biomedical scientific research, the question of how to build animal models is usually considered, because there are currently no or should not be conducted on patients to clarify the mechanism and efficacy of many experiments. Will b...
2022-02-04Acute renal failure model of dog renal artery contraction: Take a 10-20 kg male dog, anesthetize with pentobarbital sodium 30 mg/kg, and expose the left renal artery surgically. Clamp it for 1 hour, then relax, reperfuse, and collect urine from the u...
2022-02-04
Tumor cells can be divided into benign and malignant cells; cancer cells are malignant and spread. Tumor cells include cancer cells, and their common feature is cells that are out of control at the genetic level and can proliferate indefinitely. Canc...
2022-02-04![[Animal Modeling]-Gender Wars in Genes Both male and female fruit flies need a certain gene, but they are used for different purposes-how can such genes evolve?](/./uploads/images/20200905/e4a4cc3dce563.png)
As we all know, when a species needs to change to adapt to its specific needs, evolution can be of great help...
2022-02-04Researchers in the laboratory have discovered a new method of using the regeneration ability of stem cells in the laboratory to regenerate dog teeth in the open laboratory of \\\"Gene and Stem Cell Technology\\\" of Kazan Federal University...
2022-02-04Replication method Oral Porphyromonas gingivalis to periodontitis model animals. 4 days before the experiment, an adult rat weighing 250 g was injected intramuscularly with kanamycin or ampicillin at a dose of 20 mg per head...
2022-02-04The exquisite Mongolian gerbils are raised in separate cages and can eat freely. In addition to general hygiene requirements, in order to avoid cramps, please keep the room quiet when feeding and do not make any noise or move the cage...
2022-02-04Adenine produces 2,8-dihydroxyadenine through the action of xanthine oxidase deposited in the glomerulus and renal interstitium, forming foreign body granulomatous inflammation, and reacting to block the tubules of the renal tubules. Cystic expansion...
2022-02-04Replication method Inject pentobarbital sodium (30 mg/kg body weight) intraperitoneally into rats of 180 to 220 g to destroy the attachment of the gum epithelium after anesthesia, and then destroy the neck of the tooth (collected by the tooth)...
2022-02-04The breeding method uses Keyes 2000 mixed feed (fructose 56%, decomposable milk powder 28%, wheat flour 6%, yeast 4%, alfalfa meal 3%, animal liver meal 1%, salt 2%) and a small amount of vegetables in adult golden hamsters After 6 weeks of micro-his...
2022-02-04A 3.0 silk thread was used to ligate the gingival margin of the neck of the ferret test tooth. After 14 days, the animal’s gums became red and swollen and bleed easily when palpated...
2022-02-04Breeding method Healthy rhesus macaques (Rhesus macaques) and cynomolgus monkeys (M.fascicularis) between 3 and 6 years old are injected intramuscularly with 0.15 ml/kg body weight for fast sleep, and then re-anaesthetized in the nose and trachea...
2022-02-04