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Since the establishment of the HBV surface antigen detection system in the 1960s, chimpanzees are the first animals that are sensitive to human HBV. Chimpanzees infected with intravenous hepatitis B virus isolated from the serum of patients with hepa...
2022-02-03Partial reverse introduction models (also called partial dorsal root removal models) are divided into two types. One is to cut the dorsal root and keep the dorsal root part, and the other is to remove the dorsal root part. In 1958, Liu and Chambers u...
2022-02-03The experimental equipment is operating under conditions close to the design load, and the measurement continues for more than 48 hours...
2022-02-02Except for pathogens that need to be excluded from clean animals, there are no major potential infectious diseases or pathogens that cause conditional diseases and interfere with scientific experiments...
2022-02-021) Issue 1. The electrical load of the production area (animal experiment area) of the barrier environment facility should be level 2 or higher. Or prepare a backup power supply. 2, barrier environment facilities should install special powe...
2022-02-02Oleic acid is a highly toxic fatty acid. When oleic acid is injected into the left renal artery, renal tubular epithelial cells swell and die, interstitial edema, intravascular renal ischemia and severe renal microcirculation. It is impaired and rena...
2022-02-02The measurement shall be performed after the completion of the facility, after 48 hours of operation of the air conditioning system or during the normal operation of the facility. During the measurement process, the breeding/breeding area and experim...
2022-02-02Intraperitoneal injection of diazyl am 5 mg/kg and ketamine 50 mg/kg, anesthetize 100-150 g male SD rats, and perform left nephrectomy through midline incision...
2022-02-02Commonly used animals are adult SD or Wistar rats, 120-150g rats, anesthetized with diazepa 5mg/kg and ketamine 50mg/kg, prone position, fixed below the abdomen...
2022-02-02Since the 1960s, the chemical induction method has been started very early, and has become the most mature and commonly used method for preparing IBD models. There are many types of chemical stimulants, such as acetic acid, sodium dextran sulfate, so...
2022-02-02Caerulein is an analog of cholecystokinin (CCK). Cholecystokinin is a polypeptide hormone composed of 33 amino acids. Its main physiological function is to stimulate the contraction of the gallbladder and the relaxation of the Oddi sphincter, promote...
2022-02-02The lateral hydraulic shock brain injury model involves the rapid injection of a certain amount of normal saline into the cranial cavity, causing deformation and displacement of the brain tissue...
2022-02-02Pancreatic cancer is a highly malignant tumor with a poor prognosis. Pancreatic cancer is insidious, difficult to diagnose early, and is prone to liver metastasis, peritoneal spread or local recurrence, and insensitivity to chemotherapy drugs...
2022-02-02The researchers transplanted human liver cells into immunodeficient mice and allowed them to grow in the mice, gradually forming a human-mouse chimeric liver. In this animal model, HBV can survive in human liver cells and be humanized, mouse hepatiti...
2022-02-02Acetaldehyde is an intermediate metabolite of ethanol, which directly damages the liver and converts coenzyme I (NAD) into reduced coenzyme I (NADH) in the liver, thereby reducing the ratio of NAD/NADH. It inhibits the tricarboxylic acid cycle, and t...
2022-02-02Methionine-choline deficiency (MCD) diets are commonly used to induce classic NAFLD animal models. MCD diet is rich in carbohydrates (40%) and fat (10%), but lacks methionine and choline, which are involved in the oxidation of fatty acid β in liver c...
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