![[Animal modeling - Pharmacodynamic evaluation] - Coronary artery balloon induced myocardial ischemia model](/./uploads/images/default/default.png)
After anesthesia, the animal undergoes artificial respiration. After thoracotomy from the 4th or 5th intercostal space, the anterior descending branch of the left coronary artery is separated by about 1cm (or a segment of the left circumflex branch) ...
2024-07-02![[Animal modeling - Pharmacodynamic evaluation]- Animal model of fecal roundworm infection](/./uploads/images/default/default.png)
The fecal roundworm is the only worm that has both a complete free living generation and a parasitic generation...
2024-07-02![[Animal Modeling - Pharmacodynamic Evaluation] - Toxoplasma gondii infection animal model](/./uploads/images/default/default.png)
Toxoplasma gondii is a common parasitic protozoa that seriously affects human health worldwide...
2024-07-02
Experimental miniature pigs, both male and female, weighing (16 ± 3.0) kg; Medication: pentobarbital; Instrument: RM-6008 8-channel physiological recorder...
2024-07-02![[Animal Modeling Pharmacodynamic ]Evaluation Electrical Stimulation Induced Myocardial Ischemia Model](/./uploads/images/default/default.png)
Electric stimulation of the right hypothalamic dorsomedial nucleus and optic nerve edge area in animals, with stimulation parameters of 0.2ms wave width, 50 times/s frequency, weak stimulation (12V) and strong stimulation (60V). First, weak stimulati...
2024-07-02
To investigate the relationship between the protective effect of propofol on cerebral ischemia-reperfusion injury and gap junctions and its possible mechanism...
2024-07-01
To screen for microsatellite loci suitable for the detection of cat genetic quality...
2024-07-01![[Animal modeling - Pharmacodynamic evaluation] - Swine heart failure model induced by rapid right ventricular pacing](/./uploads/images/default/default.png)
Intravenous injection of ketamine 10mg/kg, atropine 0.5mg, and diazepam 1.0mg/kg. After successful anesthesia, lie on your back and establish a venous access. Open the brachiocephalic vein and insert the endocardial pacing electrode into the right ve...
2024-07-01![[Animal Modeling - Pharmacodynamic Evaluation] - High fat Feed Induced Hyperlipidemia Animal Model in Rabbits](/./uploads/images/default/default.png)
Feeding animals with high-fat and high cholesterol feed can cause hyperlipidemia in the short term...
2024-07-01
Administer Triton WR-1339 intravenously or intraperitoneally, with intravenous injection of 400mg/kg once...
2024-07-01
After anesthesia, the animal is placed in an abdominal position, starting from 1.5-2cm beside the spine, along the rib edge on the right side, and making a 4cm skin incision on the left side about two fingers wide at the rib edge. The subcutaneous ti...
2024-07-01![[Animal modeling - Pharmacodynamic evaluation] - Sucrose induced hypertensive rat model](/./uploads/images/default/default.png)
Due to high sugar intake, SD rats can develop insulin resistance and hyperinsulinemia, leading to an increase in blood pressure. The possible mechanism of the latter is: ① insulin induced sodium water retention; ② Stimulating sympathetic nervous syst...
2024-07-01![[Animal Modeling - Pharmacodynamic Evaluation] - Rabbit Brain Edema Model Induced by Typhoid Lipopolysaccharides](/./uploads/images/default/default.png)
After animal anesthesia, the common carotid artery is surgically separated and a right ventricular catheter is inserted. A brain pressure gauge is connected to measure ventricular pressure, and an amplifier can also be connected to monitor intracrani...
2024-07-01![[Animal Modeling - Pharmacodynamic Evaluation] - Pertussis Bacterial Liquid Induced Brain Edema Model in Rabbits](/./uploads/images/default/default.png)
After anesthesia, the animal is placed in a supine position and a 5cm incision is made at the midline of the neck to expose the right common carotid artery, separate the internal carotid artery, ligate the collateral branch that did not enter the sku...
2024-07-01![[Animal Modeling Pharmacodynamic Evaluation] - Traumatic Brain Edema Model in Rats](/./uploads/images/default/default.png)
The animal in the modeling group underwent surgery to expose the left parietal bone. A bone hole with a diameter of 5.0mm was drilled along the midline of the sagittal suture and 1.5mm behind the coronal suture, exposing the dura mater. The lower end...
2024-07-01![[Animal Modeling - Pharmacodynamic Evaluation] - Rabbit Lung Candida albicans Infection Model](/./uploads/images/default/default.png)
36 New Zealand white rabbits with large ears, 18 in the experimental group and 18 in the control group. On the 1st to 5th day of the experiment, daily intravenous injection of 440mg/m2 of cytarabine was administered to the ear margin, and immunosuppr...
2024-07-01