【Animal modeling】-β-aminopropionitrile-induced rat model of dissecting aneurysm establishment

To explore the effect of β-aminopropionitrile on the wall of the aorta in mice, and to compare the pathogenesis of human dissecting aneurysm, in order to further explore the animal model of dissecting aneurysm with the characteristics of human diseas...

2024-04-30

【Animal Modeling】-Comparative study on the establishment of allergic conjunctivitis mouse models under different conditions

To establish a mouse model of allergic conjunctivitis under the conditions of different antigens, different stimulation routes and different ages of mice. The establishment provides new ideas and methods...

2024-04-30

【Animal modeling】-Comparison of imiquimod on the induction of psoriasis-like skin lesions in BALB/c and C57BL/6 mice

To observe the difference and mechanism of imiquimod in the induction of psoriasis-like skin lesions in different strains of mice...

2024-04-29

[Animal modeling] - Establishment of a mouse model of pregnancy diabetes induced by high-fat diet combined with STZ

To explore a stable and reliable method for establishing a mouse model similar to gestational insulin resistance...

2024-04-28

[Animal modeling] - Optimization of AOM/DSS colon cancer model and exploration of changes in gut microbiota

To optimize the method of modeling colitis associated colon cancer using oxidized azomethane combined with sodium gluconate sulfate and explore the pathogenesis of gut microbiota in CAC...

2024-04-28

Comparison of different regimens in isoproterenol induced chronic heart failure model in animal modeling

To compare animal models prepared with three different regimens and explore a stable, reliable, and reproducible mouse model of chronic heart failure...

2024-04-28

[Animal modeling] - construction and evaluation of a mouse model of chronic restrained intestinal stress injury

Based on the characteristics of social psychological stress leading to inflammatory bowel disease, irritable bowel syndrome, and a series of other diseases, an experimental chronic restraint mouse intestinal stress injury model was established to exp...

2024-04-28

【 Animal Modeling 】 - Inflammation and coagulation dysfunction in a rat model of sepsis with compound infection

To explore the changes in coagulation function and inflammation levels during the course of sepsis...

2024-04-28

[Animal Modeling] - Progress of Tripterygium wilfordii glycoside induced early onset ovarian insufficiency model in mice at different time points

To explore the changes in relevant indicators of early onset ovarian insufficiency (POI) mouse model induced by Tripterygium wilfordii glycosides, and determine the optimal time point for intervention measures...

2024-04-28

【Animal modeling】-Effect of Astragalus on endoplasmic reticulum stress response in vascular remodeling in hypertensive rats

To study the effect of Astragalus on endoplasmic reticulum stress response (ERS) in vascular remodeling in hypertensive rats, and to explore the molecular mechanism of its vascular protection...

2024-04-27

【Animal Modeling】-The neuroprotective effect of total flavonoids of Mongolian herb Xiangqinglan on Parkinson\\\\\\\\

To investigate the neuroprotective effect of the total flavonoids of Mongolian medicine Xiangqinglan on MPTP-induced Parkinson\\\\\\\\\\\\\\\'s model mice...

2024-04-27

[Animal modeling] - Analysis of the intervention treatment of Taohe Chengqi Decoction on the rat model of hepatic encephalopathy

To investigate the effect of Taohe Chengqi Decoction (without licorice) on hepatic encephalopathy induced by thioacetamide (TAA) in rats...

2024-04-27

【Animal modeling】-Experimental study on loperamide hydrochloride-induced slow transit constipation model in mice

To compare the differences between the models induced by loperamide hydrochloride in slow transit constipation induced by loperamide hydrochloride and different doses and time, and to explore the establishment of a stable loperamide hydrochloride-ind...

2024-04-25

【Animal Modeling】-Preliminary Study on Rhesus Monkey Model Infected by Human Coxsackie B2 Virus

To provide experimental methods and technical support for the establishment of human coxsackie B2 virus infection model in rhesus macaques by preliminarily analyzing the infection characteristics of human coxsackie B2 virus in rhesus monkeys through...

2024-04-25

[Animal modeling] - Establishment and evaluation of an animal model of skin pruritus in guinea pigs

To optimize the dose of histamine and 4-aminopyridine (4-AP) by central composite design response plane method, in order to establish a new model of pruritus in guinea pigs...

2024-04-25

[Animal modeling] - Comparative study on spontaneous and induced type 2 diabetes mouse models

To compare the differences in glucose metabolism, insulin resistance and inflammatory reaction between spontaneous and induced type 2 diabetic mouse models...

2024-04-24