【Animal Modeling】-Establishment of human hepatoma cell orthotopic xenograft model in mice and a comparative study of its characteristics

To select 3 strains of human hepatoma cells and inoculate them in the liver tissue of 4 different immunodeficient mice to establish and compare the orthotopic transplantation tumor models of human hepatoma cells...

2024-03-11

【Animal Modeling】-Construction of BMP-9 Gene Knockout Mice

To use CRISPR/Cas9 technology to knock out the Bmp9 gene fragment in the mouse genome to construct Bmp9 knockout mice...

2024-03-11

【Animal modeling】-Dynamic comparative study of blood and urine biochemistry between two modeling methods for kidney stones

To construct two models of renal calculi in rats, and to provide support for the exploration of the etiology of nephrolithiasis...

2024-03-11

【Animal modeling】-Effect of simvastatin PLGA sustained-release microspheres on intervertebral disc degeneration in rats

To investigate the efficacy of local injection of simvastatin PLGA sustained-release microspheres in the treatment of intervertebral disc degeneration in rats...

2024-03-11

【Animal modeling】-Effect of Roux-en-Y gastric bypass on liver and peripheral insulin sensitivity in type 2 diabetic rats

To observe the changes of insulin sensitivity in the liver and peripheral tissues of type 2 diabetic rats at different times after RYGB and to preliminarily explore the possible mechanism...

2024-03-07

【Animal modeling】-Efficacy observation and action pathway of Eucommia ulmoides extract on lipopolysaccharide-induced mastitis mice

To study the therapeutic effect and mechanism of Eucommia ulmoides extract on mastitis in mice...

2024-03-07

[Animal modeling] - Changes of C-reactive protein and inflammatory factors in the high altitude multiple organ dysfunction syndrome model of the Fenma pig

To study the tumor necrosis factor (TNF) in the high altitude multi organ dysfunction syndrome (MODS) model of pteridophyte pigs- α Interleukin-1 β And the change characteristics of C-reactive protein in the process of inflammatory reaction...

2024-03-07

【Animal Modeling】-Establishment and evaluation of a rat model of acute lung injury induced by smoke inhalation from ship fires

To establish a temperature-controllable rat model of acute lung injury induced by ship fire smoke inhalation using various composite materials as combustion materials...

2024-03-07

[Animal modeling] - Preliminary study on the effect of lipopolysaccharide on lung tissue of naked mole rats

To observe and analyze the effects of lipopolysaccharide (LPS) on the morphological structure and pathological indexes of lung tissue in nude mole rats, and to explore whether there is LPS tolerance in nude mole rats...

2024-03-07

[Animal modeling] - creating a rat model of subarachnoid hemorrhage by puncturing the internal carotid artery

To introduce in detail the method and process of making a rat subarachnoid hemorrhage model through a combination of graphics and text; Improve and innovate the model to better simulate subarachnoid hemorrhage caused by clinical aneurysm rupture...

2024-03-06

【Animal Modeling 】- Establishment of NAFLD Model in Long Clawed Gerbils and Its Genetic Study

In the post genomic era, the long clawed gerbil also needs to conduct in-depth research with new technologies in order to achieve sustainable development...

2024-03-06

【 Animal modeling 】 - Regulatory effect of budesonide on IL-22 in an asthma mouse model

To observe the role of interleukin-22 (IL-22) in asthma models and study the regulatory effects of budesonide on airway inflammation and IL-22 in asthma mouse models...

2024-03-06

Establishment of an animal model of EV71 virus infection in primary renal epithelial cells of tree shrews

To establish an EV71 infection model on primary kidney cells of tree shrews...

2024-03-06

Construction of an animal model of chronic simple lichen in the external genitalia of SD rats and expression of protease activated receptor 2

To establish an animal model of chronic simple lichen in the external genitalia of SD rats, study the expression of protease activated receptor 2 in the model rat external genitalia skin lesions, and provide an ideal animal model for LSC...

2024-03-06

[Animal modeling]- establishment of a mouse model of skin adverse reactions induced by erlotinib

Erlotinib (trade name: Trocaine) is a new targeted drug for the treatment of non-small cell lung cancer. In recent years, it has been widely used in clinical practice, but there are many side effects, with rash being the most common and difficult for...

2024-03-06

[Animal Modeling] - Research Progress of Human Tumor Xenotransplantation Models in Precision Oncology Medicine

Cancer is a series of heterogeneous diseases caused by mutations in oncogenes and tumor suppressor genes caused by physical, chemical, viral and other carcinogenic factors...

2024-03-06