【Animal modeling】-Isolation and identification of mouse CD4+ T cell exosomes

To investigate whether CD4+ T cells have the ability to secrete exosomes, and the possibility of CD4+ T cell exosomes participating in inflammation and tumor immune processes...

2022-07-07

【Animal modeling】-The role of MicroRNA-137 and AngⅡ in cardiac remodeling in spontaneously hypertensive rats

To investigate the role of microribonucleic acid 195 (MicroRNA-137, miRNA-137), TGF-β1/Smads signal transduction pathway and angiotensin II (Ang II) in cardiac remodeling in spontaneously hypertensive rats (SHR)...

2022-07-07

【Animal Modeling】-Lactobacillus rhamnosus culture supernatant prevents Escherichia coli meningitis by inhibiting NF-κB pathway

To investigate whether Lactobacillus rhamnosus supernatant (LGG-CM) can block bacterial meningitis caused by Escherichia coli K1 (E. coli K1) strain by inhibiting NF-κB pathway in vitro...

2022-07-07

【Animal modeling】-Effect of curcumin on blood and tissue neutrophils in rats with heat stroke in desert dry heat environment

To investigate the effect of curcumin pretreatment on the changes of blood and tissue neutrophils in rats with heat stroke in desert dry heat environment...

2022-07-07

【Animal Modeling】-Comparison of Histological Observation of Different Sectioning Methods and Staining Methods of Rat Coccyx Intervertebral Disc

To compare the advantages and disadvantages of different slicing methods and staining methods of rat tail intervertebral disc, and lay a theoretical foundation for the corresponding clinical diagnosis and experimental research...

2022-07-07

【Animal Modeling】-Study on the anxiety-like behavior of rats induced by different stress methods at different time points

To compare the biological characteristics of several different stress methods to establish an anxiety rat model from different time points, and to provide an experimental basis for finding the most suitable modeling method...

2022-07-07

【Animal modeling】Effect of -17βestradiol on propofol-induced apoptosis of cortical neurons

To investigate the effect and mechanism of 17β-estradiol on the apoptosis of primary cultured cortical neurons induced by propofol...

2022-07-07

【Animal modeling】-Evaluation of the detection method of intestinal mucosal barrier damage in diabetic rats and discussion of the hypoglycemic effect of propolis

To analyze and evaluate the detection method of intestinal mucosal barrier function in diabetic rats, and to explore whether propolis exerts hypoglycemic effect by repairing intestinal mucosal barrier...

2022-07-07

【Animal modeling】-PKH26 and Hoechst 33258 combined tracing of Uncv hairless mouse iRhom2 and its mutant proteins

To use PKH26 and Hoechst 33258 to trace the localization of Uncv hairless mouse iRhom2 and its mutant proteins in Vero cells...

2022-07-07

【Animal modeling】-Establishment of a porcine cornea test for acute eye irritation of a disinfectant

To establish an in vitro method for the detection of acute eye irritation of disinfected products using porcine cornea...

2022-07-07

【Animal Modeling】-Aconitine-induced rapid ventricular arrhythmia model

Arrhythmia caused by aconitine is mainly related to inhibiting membrane Na + channel inactivation, promoting continuous Na + influx and improving the autonomy of ectopic pacemakers...

2022-07-07

【Animal modeling】- Down-regulation of miR-128-3p alleviates inflammatory response and lung histomorphology in acute lung injury in septic rats

To investigate the effect of down-regulation of miR-128-3p on inflammatory response and lung histomorphology in acute lung injury in septic rats...

2022-07-06

【Animal Modeling】-Evaluation of the effect of midazolam and butorphanol on anesthesia in mice before isoflurane anesthesia

To observe the anesthesia effect and internal environment stability of mice receiving midazolam combined with butorphanol before isoflurane anesthesia, and evaluate the safety...

2022-07-06

【Animal modeling】-The expression significance of c-Myc, RhoA and YAP in chronic kidney disease induced by the expression of adenosine

To observe the expressions of renal c-Myc, RhoA and YAP proteins in adenine-induced chronic kidney disease model in rats and their relationship with tubulointerstitial fibrosis...

2022-07-06

【Animal modeling】-Exploration of the effect of pomegranate tonic syrup on anemia in Wistar rats

To investigate the effect of pomegranate tonic syrup on anemia in Wistar rats...

2022-07-06

【Animal Modeling】-The effect of miR-328 on the expression of L-type calcium channel in thoracic aorta of hypertensive rats by exercise

To investigate the promoting effect of microRNA-328 (miR-328) in improving the expression of L-type voltage-gated calcium channel in thoracic aortic smooth muscle cells of hypertensive rats by aerobic exercise...

2022-07-06