[Animal Modeling - Efficacy Evaluation] - Trichinella Infection Animal Model

Trichomoniasis is a zoonotic parasitic disease that can host humans, pigs, mice, cats, dogs, and various wild animals...

2024-09-23

Animal Modeling - Pharmacological Evaluation - Animal Model of Cerebral Arteriovenous Malformation

The previous animal models of cerebral arteriovenous malformations were arteriovenous fistulas without a true malformation mass structure. Massoud et al. established for the first time in 1994 an animal model of cerebral arteriovenous malformation co...

2024-09-20

[Animal Modeling - Pharmacological Evaluation]- Animal Model of Craniocerebral Firearm Injury

Mixed breed dogs, regardless of gender, weighing 15-20kg. After intravenous injection of pentobarbital sodium anesthesia at a dose of 30mg/kg body weight, tracheal intubation was performed. Place the dog on the shooting target platform, fix its head ...

2024-09-20

[Animal Modeling Drug Efficacy Evaluation] - Diffuse and Focal Brain Injury Model in Rats

Organic glass tube: An organic glass tube with a length of 2m, an inner diameter of 19mm, and an outer diameter of 26mm, fixed at 3 points on the wall, with its lower end 15cm above the ground, for placing sponge beds and rats. Drill a small hole wit...

2024-09-20

【Animal Modeling Drug Efficacy Evaluation】 - Chronic Renal Failure Model in 7/8 Renal Resection Rats

Under ether anesthesia, ligate and remove 3/4 of the left kidney through a lumbar incision, and remove the right kidney one week later, for a total of 7/8 kidneys, to establish a chronic renal insufficiency model...

2024-09-20

【Animal Modeling Drug Efficacy Evaluation】 Stress Hypertension Model

Repeated combination of unconditional stimuli (such as injection of adrenaline, angiotensin, or electrical stimulation) with conditioned stimuli can induce hypertension in animals such as dogs, rats, and rabbits...

2024-09-19

[Animal modeling - Drug efficacy evaluation] - Extrarenal bandaging induced hypertension model

Also known as extrarenal compression hypertension model, it can be divided into two kidney one bundle type (one kidney bundle, bilateral kidney preservation), one kidney one bundle type (one kidney bundle, contralateral kidney resection), and two kid...

2024-09-19

[Animal modeling - Drug efficacy evaluation] - Renal vascular hypertension model

The renal vascular hypertension model is a model in which animal renal artery stenosis leads to an increase in blood pressure. According to different experimental methods, it can be divided into two kidney one clip type (left renal artery stenosis, b...

2024-09-19

[Animal modeling - efficacy evaluation] - Atherosclerosis model induced by high fat and high sugar diet in rabbits

A significant increase in plasma glucose concentration leads to an increase in blood viscosity. Hyperglycemia can also generate superoxide stress, increase the generation of oxygen free radicals and advanced glycation end products (AGEs) in the body,...

2024-09-19

[Animal modeling - efficacy evaluation] - Vitamin D induced atherosclerosis model in rats

Compared with the previous model of atherosclerosis induced by feeding animals with vitamin D, the one-time intraperitoneal injection of vitamin D has the advantages of simpler operation, lower cost, shorter time and higher success rate. This model h...

2024-09-19

[Animal modeling - efficacy evaluation] - macaque cerebral atherosclerosis animal model

This model was created using primate macaques and fed a high-fat diet for 16-28 months. Compared with other animal models, its cardiovascular anatomy and physiological functions are closer to those of humans, but the modeling time is longer...

2024-09-19

[Animal modeling - efficacy evaluation] - quail atherosclerosis animal model

This model is modeled using quails, with a simple method and high modeling rate. But after 32-36 weeks of high-fat feeding and 4-6 weeks of basic feed feeding, the thickness of the aortic intima and plaque score were significantly reduced compared to...

2024-09-19

[Animal modeling - Drug efficacy evaluation] - Acute renal failure dog model caused by abdominal open injury combined with seawater immersion

20 healthy adult beagle dogs weighing 13-20kg; Reagent: Artificial seawater [Main indicators: osmotic pressure (1250 ± 11.52) mmol/L, pH 8.2, sodium ion (630 ± 5.33) mmol/L, potassium ion (10.88 ± 0.68) mmol/L, chloride ion (658.8 ± 5.25) mmol/L, sea...

2024-09-19

【Animal modeling - Drug efficacy evaluation】 - Chronic renal failure rat glomerulosclerosis model

After one week of adaptation in the model animals, right nephrectomy was performed. On the 7th day after surgery, a 2g/L solution of doxorubicin was injected into the tail vein at a dose of 5mg/kg. On the 30th day after surgery, doxorubicin was repea...

2024-09-19

[Animal Modeling - Pharmacological Evaluation] - Small Pig Root Absorption Model

　　Root resorption is a common and difficult complication in orthodontic treatment. There are many factors that can cause root resorption, including age, gender, nutritional status, type of orthodontic appliance, magnitude of orthodontic force, orthod...

2024-09-18

[Animal modeling - Efficacy evaluation] - Repair of peri implant bone defects in miniature pigs

Implant restoration has been increasingly widely used in clinical practice, but tooth loss due to trauma, tumors, periodontal disease, and other reasons is often accompanied by excessive absorption of alveolar bone, resulting in insufficient bone mas...

2024-09-18