【Animal Modeling - Efficacy Evaluation】 - Genetic Engineering Animal Model of Catecholamine Substance Action System

Catecholamines include adrenaline, norepinephrine, dopamine, and their metabolites...

2024-09-25

[Animal Modeling - Pharmacological Evaluation] - Primate Parkinson\'s Disease Model

Animals: Healthy rhesus monkeys, male or female, weighing 3.7-5.5kg, aged 4-8 years old; Drug: N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), physiological saline, apomorphine...

2024-09-24

[Animal Modeling Drug Efficacy Evaluation] - Animal Model of Epilepsy Induced by Hymenonic Acid

Healthy male Wistar rats were injected intraperitoneally with physiological saline at doses of 6mg/kg, 10mg/kg, and 14mg/kg, respectively, to establish a good epilepsy model. Generally, 10mg/kg KA intraperitoneal injection has better modeling effect...

2024-09-24

[Animal Modeling - Pharmacological Evaluation] - Partial Simple Epilepsy Model in Rats

rats, male or female, weighing 200-300g; drugs: pentobarbital, FeCl3 solution; Equipment: Rat brain stereotaxic device...

2024-09-24

[Animal Modeling - Pharmacological Evaluation] - Non immune Chronic Renal Failure Rat Model

Male SD rats, 10-12 weeks old, weighing 180-220g; Medications: pentobarbital, benzalkonium bromide...

2024-09-24

Animal Modeling Drug Efficacy Evaluation -5/6 Renal Resection Rat Chronic Renal Failure Model

After trimming the hair at the kidney position on the back of the rat, fix it. Under ether anesthesia, an incision was made at the left dorsal kidney position (in the sham surgery group, only the incision was made and the kidney was not cut). After f...

2024-09-24

[Animal modeling - efficacy evaluation] - primary diabetes BB rats

BB Wistar rat is a spontaneous diabetes animal model...

2024-09-23

[Animal Modeling - Pharmacological Evaluation] - Blood Volume Overload Cardiac Insufficiency Model

The model of heart failure caused by blood volume overload can be divided into acute and chronic types. The acute blood volume overload model is commonly used in animals with already heart failure, usually by rapidly inputting colloidal solution to a...

2024-09-23

[Animal modeling - Drug efficacy evaluation]- Central excitation and inhibition model

Administer 60mg/kg pentylenetetrazol or 200mg/kg nicotine intravenously to animals...

2024-09-23

[Animal modeling - Drug efficacy evaluation] - Animal infection model of Burkholderia mallei

Selecting albino guinea pigs as experimental subjects, the bacterial suspension was intraperitoneally inoculated into guinea pigs at a dilution of 2 × 10000000 CFU/ml...

2024-09-23

[Animal modeling - efficacy evaluation] - Pathological mechanism of conjunctival injury in diabetes model rabbits

By detecting the matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in conjunctival tissue cells of diabetes rabbits fed with high-fat and high-sugar diet plus streptozotocin, the relationship between them and...

2024-09-23

[Animal modeling - efficacy evaluation] - animal model of diabetes caused by partial pancreatectomy

SD rats were intraperitoneally injected with a 5% pentobarbital sodium physiological saline solution at a dose of 40-50 mg/kg body weight. The rats were fixed in a dorsal position on a surgical plate, and their abdomen was shaved and disinfected with...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Preparation of Tree Shrew Hepatitis B Animal Model

Ten tree shrews were used. For the first time, 0.5ml of serum (1 × 10 ^ 8 CID, chimpanzee infection dose) was intravenously injected from two asymptomatic human carriers of hepatitis B virus. Three days later, an equal amount of the same human serum ...

2024-09-23

[Animal modeling - Drug efficacy evaluation] - Rabbit conjunctivitis model induced by bufotalin tincture

Bufalin tincture has strong irritant properties and can stimulate the conjunctiva of rabbit eyes, causing certain degree of damage, thus replicating the acute irritant conjunctivitis model in rabbits...

2024-09-23

[Animal Modeling Drug Efficacy Evaluation] - Establishment of Vascular Dementia Animal Model by Cerebral Embolism Method

Take sterile naturally dried blood clots from the same type of rats, grind them and sieve them through a 200 μ m sieve for later use. When applied, take 0.5ml of physiological saline and 100mg of blood clot homogenate to prepare a suspension. Measure...

2024-09-23

[Animal modeling - efficacy evaluation] - establishment of diabetes animal model after total pancreatectomy

Adult hybrid dogs weighing 10-15kg, intramuscular injection of 30mg/kg body weight of 3% pentobarbital sodium, tracheal intubation. One side of the femoral artery and vein were respectively intubated to measure arterial pressure and collect blood sam...

2024-09-23