【Animal Modeling - Pharmacological Evaluation】 - Mercury Raising Induced Canine Kidney Disease Model

Before the experiment, create a ureteral fistula or bladder fistula in the dog, and inject a 2% mercuric solution subcutaneously into the abdomen of the model animal at a dose of 20mg/kg...

2024-08-28

[Animal Modeling Drug Efficacy Evaluation]- Egg Protein Arthritis Model

Dissolve egg protein in physiological saline to prepare a 20g/L solution, and then mix it thoroughly with an equal amount of Freund\'s adjuvant. Subcutaneous injection of animal back, once a week, for 3 consecutive weeks to induce sensitization. Two ...

2024-08-27

[Animal Modeling - Efficacy Evaluation ]- Adjuvant Arthritis Animal Model

Adjuvant arthritis (AA), also known as Freund\'s adjuvant arthritis, was founded by bacteriologist Freund in the 1950s and is the basic method for animal models of immune arthritis...

2024-08-27

[Animal Modeling - Pharmacological Evaluation] - Osteoporosis Animal Model

Female experimental rats were anesthetized by intraperitoneal injection of 2% pentobarbital sodium at a dose of 40mg/kg body weight. A sterile midline incision was made in the lower abdomen, and the abdominal muscles were bluntly separated from the p...

2024-08-27

[Animal Modeling - Pharmacological Evaluation] - Rat Fluoroplaque Animal Model

Select female rats weighing 70-100g after weaning, prepare different concentrations of sodium fluoride solution for poisoning with distilled water, and calculate the poisoning volume based on 0.5ml/100g body weight...

2024-08-27

[Animal modeling - Drug efficacy evaluation] - Establishment of periodontitis model through dietary habits

Adult golden hamsters were fed with Keyes 2000 formula feed (56% fructose, 28% skimmed milk powder, 6% flour, 4% yeast, 3% alfalfa flour, 1% animal liver powder, 2% salt) and a small amount of vegetables. After 6 weeks, microscopic histopathological ...

2024-08-27

[Animal Modeling Drug Efficacy Evaluation] - Recurrent Oral Ulcer Animal Model

Firstly, place the dialysis bag in a 0.5mol/L EDTA solution, boil for 0.5 hours, discard the solution, replace with distilled water and boil again 3 times. Then store it in distilled water containing 0.01% sodium azide and store it at 4 ℃ for future ...

2024-08-27

[Animal Modeling - Pharmacological Evaluation] - Oral Ulcer Animal Model

SD rats weighing 150-180g. Take a 6cm long glass tube with a diameter of 3mm at the lower end, and insert a small cotton ball inside. Make the bottom of the small cotton ball level with the lower opening of the glass tube, and then drip 90% carbolic ...

2024-08-27

[Animal Modeling - Pharmacological Evaluation] - Mercury Raising Induced Kidney Disease Model in Rabbits

male rabbits weighing 2-2.5kg; Drug: mercuric chloride...

2024-08-27

[Animal Modeling - Pharmacological Evaluation] - Rabbit Oleic Acid Type Acute Lung Injury Model

Healthy rabbits, male or female, weighing 2.0-2.5kg; Medications: Oleic acid, pentobarbital, heparin physiological saline...

2024-08-27

[Animal Modeling - Pharmacological Evaluation] - Pingyangmycin induced Lung Injury Model in Rats

Healthy SD rats, male or female, weighing (210 ± 23) g; Drug: Pingyangmycin, physiological saline; Instrument: Syringe...

2024-08-27

[Animal modeling - Drug efficacy evaluation] - Serum nephritis model

rabbit; Drug: Bovine serum albumin (BSA)...

2024-08-27

【Animal Modeling - Pharmacological Evaluation】 - Cationized Bovine Serum Albumin Nephritis Model in Rabbits

rabbits, weighing 2-2.5kg; Drug: Cationized bovine serum albumin (C-BSA)...

2024-08-27

[Animal Modeling - Efficacy Evaluation] - Carbon Tetrachloride Induced Cirrhosis Animal Model

Adult male rats were intraperitoneally injected with 2ml/kg body weight of 30% CCl4 paraffin oil solution twice a week for 7 consecutive weeks...

2024-08-26

[Animal Modeling - Pharmacological Evaluation] - Ethanol Induced Liver Fibrosis Model

Adult rats were given Baijiu (ψ (C2H5OH)=0.56) 7g/kg body weight by gavage once a day in the morning for 24 weeks. Or give Baijiu corn oil pyrazole mixture by gavage once a day in the morning for 12 consecutive weeks...

2024-08-26

【Animal modeling - Drug efficacy evaluation】 - Induction of liver fibrosis model by common bile duct ligation method

Adult rats were anesthetized and their abdominal cavity was opened to locate and free the common bile duct in the mesentery of the descending duodenum. Two silk threads were threaded underneath and a \"V\" - shaped incision was made towards...

2024-08-26