
Adult rats were anesthetized by intraperitoneal injection of ether or ketamine at a dose of 100mg/kg body weight, fixed in a supine position, and opened along a transverse incision in the upper abdomen. The abdominal wall blood vessels were cauterize...
2024-08-26![[Animal modeling drug efficacy evaluation] - Ethanol gavage plus high-fat feeding model](/./uploads/images/default/default.png)
Adult rats were fed a high-fat diet (supplemented with 1% cholesterol and 5% lard on top of a low-fat diet) for one week after normal feeding. At the same time, they were orally administered with 1.5ml/kg body weight of 60% ethanol twice a day for 12...
2024-08-26![[Animal modeling - Drug efficacy evaluation] - Intestinal adhesion animal model](/./uploads/images/default/default.png)
Adult rats were fasted and deprived of water for 12-16 hours. After intraperitoneal injection of pentobarbital sodium at a dose of 40mg/kg body weight, the rats were anesthetized and placed supine on a surgical plate. The abdomen was routinely depila...
2024-08-26![[Animal Modeling - Pharmacological Evaluation]- Fetal Mouse Colonic Implantation Induced Ulcerative Colitis Animal Model](/./uploads/images/default/default.png)
Adult SD rats, aged 5-6 months and weighing 250-400g, were implanted with a colon of 3-4cm under the right renal capsule of 14-16-day-old homologous fetal rats. On postoperative days 7, 14, and 21, 5-10ml of cardiac blood was extracted for the separa...
2024-08-26
Adult rats received four immunizations on the 1st, 10th, 17th, and 24th days. The immune substance is a suspension of Escherichia coli cells killed by formaldehyde, with a concentration of 1.2 × 100000000/ml. Preparation method: Take one rat, euthani...
2024-08-26![[Animal Modeling Drug Efficacy Evaluation ]- Duodenal Reflux Surgery Induced Chronic Gastric Ulcer Animal Model](/./uploads/images/default/default.png)
Adult rats were fasted without water for 24 hours, anesthetized with pentobarbital sodium, and placed in a supine position with a midline incision. The lateral wall of the jejunum, 10cm away from the Treitz ligament, was anastomosed with the anterior...
2024-08-26![[Animal modeling drug efficacy evaluation] - HP induced chronic gastric ulcer animal model](/./uploads/images/default/default.png)
BALB/c mice, SPF grade, 5-7 weeks old, fasted for 12 hours, anesthetized and opened the abdomen. At the posterior wall of the greater curvature of the stomach, a No. 2 surgical cotton thread containing corrosive drugs (soaked in a solution of 15% c...
2024-08-26![[Animal Modeling - Pharmacological Evaluation] - Chemical Induced Acute Gastric Ulcer Animal Model](/./uploads/images/default/default.png)
Adult experimental mice were fasted and kept in water for 48 hours. They were orally gavaged with anhydrous ethanol (5ml/kg body weight dose), acetylsalicylic acid (200mg/kg body weight dose), or 0.6mol/L hydrochloric acid (10ml/kg body weight dose)....
2024-08-26![[Animal Modeling - Pharmacological Evaluation] - Gastrointestinal Anastomosis Induced Chronic Atrophic Gastritis Animal Model](/./uploads/images/default/default.png)
Adult rats were fasted without water for 18 hours, and then anesthetized with pentobarbital sodium at a dose of 30mg/kg body weight. The stomach and jejunum were exposed, and the anterior stomach about 2cm away from the pylorus and the jejunum 5-7cm ...
2024-08-26![[Animal Modeling - Pharmacological Evaluation] - Acute Gastritis Animal Model](/./uploads/images/default/default.png)
Adult male rats were fasted without water for 48 hours, orally administered with 100mg/kg body weight of acetylsalicylic acid, or 10mmol/L acetic acid or different concentrations of hydrochloric acid (1, 10, 10mmol/L), or administered with the same b...
2024-08-26![[Animal modeling - Drug efficacy evaluation] - Acid infusion method for reflux esophagitis model](/./uploads/images/default/default.png)
Apply adult rabbits weighing 2-3kg. Rabbits were fasted for 12 hours before surgery but were unable to drink water...
2024-08-26![[Animal Modeling Drug Efficacy Evaluation] - Esophageal Varicose Vein Model of Canine Portal Hypertension](/./uploads/images/default/default.png)
Adult Beagle dogs were fasted 16 days before surgery and anesthetized with 10mg/kg body weight of ketamine via intramuscular injection. The animals were then placed on the operating table for fixation...
2024-08-26![[Animal Modeling Drug Efficacy Evaluation] - Esophageal Narrowing Animal Model](/./uploads/images/default/default.png)
Adult Beagle dogs weighing 8-14kg were anesthetized by intravenous injection of pentobarbital sodium at a dose of 30mg/kg body weight. The dogs were then fixed on their side on the operating table, and the neck surgical area was routinely disinfected...
2024-08-26![[Animal Modeling - Efficacy Evaluation] - Extracorporeal Circulation Animal Model](/./uploads/images/default/default.png)
Rats were anesthetized by intraperitoneal injection of pentobarbital sodium at a dose of 30mg/kg body weight, followed by oral intubation and mechanical ventilation (frequency 60 times/min, peak airway pressure 9.0cmH2O (0.88kPa)). Left femoral art...
2024-08-26![[Animal Modeling - Pharmacological Evaluation] - Portal Hypertension Esophageal Varicocele Animal Model](/./uploads/images/default/default.png)
After fasting and water deprivation for 8 hours, rats were anesthetized using conventional methods and fixed in a supine position on the operating table. The skin was cut 2.5-3.0cm in the center of the abdomen, and the abdominal cavity was opened alo...
2024-08-26![[Animal Modeling - Pharmacological Evaluation] - Saffron Red O-induced Kidney Disease Model in Rabbits](/./uploads/images/default/default.png)
rabbits, weighing 2-3kg; Medication: Saffron Red O, Renluo Liquid...
2024-08-26