Animal Modeling Pharmacodynamic Evaluation Pituitrin Induced Myocardial Ischemia Model

Rats were intravenously injected with 0.5u/kg or 11u/kg of pituitrin, with a volume of 1 or 1.5ml, and the injection was completed within 10 or 15 seconds...

2024-07-02

[Animal modeling - efficacy evaluation] - Preparation of diabetes cardiomyopathy model

The rats were fed with a high sugar and high fat diet (10% lard, 20% sucrose, 2% cholesterol, 1% sodium cholate, 67% conventional diet) for 4 weeks, and venous blood was collected for fasting (fasting for 10 to 12 hours, during which free drinking wa...

2024-07-02

[Animal modeling - Pharmacodynamic evaluation] - Coronary artery balloon induced myocardial ischemia model

After anesthesia, the animal undergoes artificial respiration. After thoracotomy from the 4th or 5th intercostal space, the anterior descending branch of the left coronary artery is separated by about 1cm (or a segment of the left circumflex branch) ...

2024-07-02

[Animal modeling - Pharmacodynamic evaluation]- Animal model of fecal roundworm infection

The fecal roundworm is the only worm that has both a complete free living generation and a parasitic generation...

2024-07-02

[Animal Modeling - Pharmacodynamic Evaluation] - Toxoplasma gondii infection animal model

Toxoplasma gondii is a common parasitic protozoa that seriously affects human health worldwide...

2024-07-02

Animal Modeling Pharmacodynamic Evaluation - Pig Acute Myocardial Ischemia Model

Experimental miniature pigs, both male and female, weighing (16 ± 3.0) kg; Medication: pentobarbital; Instrument: RM-6008 8-channel physiological recorder...

2024-07-02

[Animal Modeling Pharmacodynamic ]Evaluation Electrical Stimulation Induced Myocardial Ischemia Model

Electric stimulation of the right hypothalamic dorsomedial nucleus and optic nerve edge area in animals, with stimulation parameters of 0.2ms wave width, 50 times/s frequency, weak stimulation (12V) and strong stimulation (60V). First, weak stimulati...

2024-07-02

【Animal modeling】-Propofol protects against cerebral ischemia-reperfusion injury and may be related to the inhibition of gap junction function

To investigate the relationship between the protective effect of propofol on cerebral ischemia-reperfusion injury and gap junctions and its possible mechanism...

2024-07-01

【Animal Modeling】-Screening of microsatellite loci for genetic analysis of experimental cat population

To screen for microsatellite loci suitable for the detection of cat genetic quality...

2024-07-01

[Animal modeling - Pharmacodynamic evaluation] - Swine heart failure model induced by rapid right ventricular pacing

Intravenous injection of ketamine 10mg/kg, atropine 0.5mg, and diazepam 1.0mg/kg. After successful anesthesia, lie on your back and establish a venous access. Open the brachiocephalic vein and insert the endocardial pacing electrode into the right ve...

2024-07-01

[Animal Modeling - Pharmacodynamic Evaluation] - High fat Feed Induced Hyperlipidemia Animal Model in Rabbits

Feeding animals with high-fat and high cholesterol feed can cause hyperlipidemia in the short term...

2024-07-01

【 Animal Modeling Pharmacodynamic Evaluation 】 - Non feeding induced hyperlipidemia animal model in mice

Administer Triton WR-1339 intravenously or intraperitoneally, with intravenous injection of 400mg/kg once...

2024-07-01

Animal Modeling Pharmacodynamic Evaluation Experimental Renal Artery Stenosis Hypertension Model

After anesthesia, the animal is placed in an abdominal position, starting from 1.5-2cm beside the spine, along the rib edge on the right side, and making a 4cm skin incision on the left side about two fingers wide at the rib edge. The subcutaneous ti...

2024-07-01

[Animal modeling - Pharmacodynamic evaluation] - Sucrose induced hypertensive rat model

Due to high sugar intake, SD rats can develop insulin resistance and hyperinsulinemia, leading to an increase in blood pressure. The possible mechanism of the latter is: ① insulin induced sodium water retention; ② Stimulating sympathetic nervous syst...

2024-07-01

[Animal Modeling - Pharmacodynamic Evaluation] - Rabbit Brain Edema Model Induced by Typhoid Lipopolysaccharides

After animal anesthesia, the common carotid artery is surgically separated and a right ventricular catheter is inserted. A brain pressure gauge is connected to measure ventricular pressure, and an amplifier can also be connected to monitor intracrani...

2024-07-01

[Animal Modeling - Pharmacodynamic Evaluation] - Pertussis Bacterial Liquid Induced Brain Edema Model in Rabbits

After anesthesia, the animal is placed in a supine position and a 5cm incision is made at the midline of the neck to expose the right common carotid artery, separate the internal carotid artery, ligate the collateral branch that did not enter the sku...

2024-07-01