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[Animal modeling] - Study on the safety and effectiveness of human umbilical cord mesenchymal stem cells in the treatment of acute lung injury in mice

[Animal modeling] - Study on the safety and effectiveness of human umbilical cord mesenchymal stem cells in the treatment of acute lung injury in mice

To investigate the safety and efficacy of human umbilical cord mesenchymal stem cells (HUC MSCs) in the treatment of lipopolysaccharide (LPS) - induced acute lung injury in mice...

2024-06-26
【Animal Modeling】-Hydrogen-rich liquid attenuates cerebral ischemia-reperfusion injury in rats through PI3K pathway

【Animal Modeling】-Hydrogen-rich liquid attenuates cerebral ischemia-reperfusion injury in rats through PI3K pathway

To investigate the effect of hydrogen-rich solution on the apoptosis of hippocampal neurons and the expression of PI3K/Akt/FoxO1 signaling pathway induced by cerebral ischemia-reperfusion in rats...

2024-06-24
[Animal modeling] - The role of villin 1 in the model of unilateral nephrectomy Habu nephritis in mice

[Animal modeling] - The role of villin 1 in the model of unilateral nephrectomy Habu nephritis in mice

To investigate the similarities and differences between unilateral nephrectomy (UNX) mouse Habu nephritis model and normal mouse Habu nephritis model in renal function, renal pathology and expression of glomerular villin 1 (VIL 1) and their molecular...

2024-06-24
[Animal Modeling - Pharmacodynamic Evaluation] - Spontaneous Vitiligo Animal Model

[Animal Modeling - Pharmacodynamic Evaluation] - Spontaneous Vitiligo Animal Model

Humans can induce local depigmentation in some animals, such as chickens, rodents, dogs, cats, and horses. These animals often have anti melanocyte antibodies in their bodies, with the most commonly used being Smyth line (SL) chickens and C57BL mice...

2024-06-19
【Animal modeling 】- Pharmacodynamic evaluation - Homologous/xenograft squamous cell carcinoma model

【Animal modeling 】- Pharmacodynamic evaluation - Homologous/xenograft squamous cell carcinoma model

Inoculating human SCC tissue or cancer cells into the back, forelimb armpits, inguinal area, lateral chest wall, or sublingual area of immunodeficient mice can produce SCC locally...

2024-06-19
[Animal modeling - Pharmacodynamic evaluation] - Gene modified squamous cell carcinoma model

[Animal modeling - Pharmacodynamic evaluation] - Gene modified squamous cell carcinoma model

Numerous genes are involved in the pathogenesis of SCC, and gene modified animal models with high or no expression of specific genes can spontaneously or externally induce SCC...

2024-06-19
Animal Modeling Pharmacodynamic Evaluation Radiation induced Cataract Animal Model

Animal Modeling Pharmacodynamic Evaluation Radiation induced Cataract Animal Model

Ultraviolet (UV) in nature is divided into UVA (315-400nm), UVB (280-315nm), and UVC (100-280nm). The atmospheric ozone can absorb UV with a wavelength less than 280nm, and what enters the ground are UVB and UVA. The most sensitive UV wavelength of t...

2024-06-19
[Animal modeling - Pharmacodynamic evaluation] - Preparation of chronic myeloid leukemia animal model using virus transfection method

[Animal modeling - Pharmacodynamic evaluation] - Preparation of chronic myeloid leukemia animal model using virus transfection method

Chronic myeloid leukemia (CML) is a type of malignant tumor that involves bone marrow hematopoietic stem cells. Ph chromosome or bcr/Abl positivity is a molecular genetic characteristic of CML patients. Therefore, using a reverse transcription virus ...

2024-06-19
[Animal modeling - Pharmacodynamic evaluation ]- Wild lily alkaloid induced pulmonary heart disease model in rats

[Animal modeling - Pharmacodynamic evaluation ]- Wild lily alkaloid induced pulmonary heart disease model in rats

The animals in the 60mg/kg modeling group were injected subcutaneously under the scapula, or injected intraperitoneally with a 60mg/kg solution of wild lily alkaloids...

2024-06-19
【Animal modeling - pharmacological evaluation】 -1. Iron trichloride induced pulmonary heart disease model

【Animal modeling - pharmacological evaluation】 -1. Iron trichloride induced pulmonary heart disease model

The animals in the modeling group were injected with 3% ferric chloride solution via the rabbit ear vein, starting at 0.5ml each time, three times a week, and gradually increasing to four times, with a total injection of 45-60ml. During the injection...

2024-06-19
【Animal Modeling】-Effect of Bushen Bujing Recipe on Tripterygium wilfordii polyglycosides-induced premature ovarian failure rat model

【Animal Modeling】-Effect of Bushen Bujing Recipe on Tripterygium wilfordii polyglycosides-induced premature ovarian failure rat model

Primary hypogonadism is defined as ovarian insufficiency with high serum follicle-stimulating hormone (FSH) levels. In women, one of the most common forms of primary hypogonadism is premature ovarian failure (POF), also known as premature menopause...

2024-06-18
【Animal modeling】-Preparation of rat thoracic aortic vascular smooth muscle cells by an improved two-step compound enzyme digestion method

【Animal modeling】-Preparation of rat thoracic aortic vascular smooth muscle cells by an improved two-step compound enzyme digestion method

This paper reports an improved method for the isolation of rat thoracic aortic vascular smooth muscle cells based on compound enzymatic digestion...

2024-06-18
【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

【Animal Modeling】-Effect of REST/NRSF on depression and anxiety-like behavior in corticosterone stress model mice

To study the expression of REST in corticosterone model mice and the effect of REST expression on depression and anxiety behavior in mice, and to explore its role in the mouse model of depression...

2024-06-18
【Animal Modeling】-Safflower Yellow Pigment Protects the Kidneys of Mice with Diabetic Nephropathy and Its Mechanism

【Animal Modeling】-Safflower Yellow Pigment Protects the Kidneys of Mice with Diabetic Nephropathy and Its Mechanism

To investigate the renal protective effect and mechanism of safflower yellow on streptozotocin-induced diabetic nephropathy in mice...

2024-06-18
【Animal Modeling】-Construction and identification of an immunohumanized mouse model of prostate cancer

【Animal Modeling】-Construction and identification of an immunohumanized mouse model of prostate cancer

To construct a mouse model of humanized immune system and transplant it into human prostate cancer cell lines, so as to be used for the research of prostate cancer immunotherapy drugs...

2024-06-18
【Animal modeling】-Protective effect of GDF11 on myocardial injury in type II diabetic mice

【Animal modeling】-Protective effect of GDF11 on myocardial injury in type II diabetic mice

To observe the protective effect of GDF11 on myocardial injury in C57BL/6J mice with type Ⅱ diabetes mellitus and the changes of myocardial apoptosis...

2024-06-18